Intake of red meat and heterocyclic amines, metabolic pathway genes and bladder cancer risk
Lin J, Forman MR, Wang J, Grossman HB, Chen M, Dinney CP, Hawk ET, Wu X
International journal of cancer · 23 citas
Etiquetas de revisión
Mezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA74880); National Cancer Institute (P50 CA091846); National Cancer Institute (K07 CA134831); National Cancer Institute (R03 CA128079); National Cancer Institute (R01 CA074880)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2012-01-19 · Int J Cancer · vol. 131 · número 8 · págs. 1892–1903
- Editorial
- Wiley
- Citado
- 33 citas · más que el 88% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Tea Polyphenols and Effects
- Palabras clave
- Bladder cancer, Gene, Medicine, Cancer, Physiology, Biology, Internal medicine, Endocrinology, Genetics
- MeSH
- humans, amines, heterocyclic compounds, prognosis, risk factors, case-control studies, follow-up studies, genotype, polymorphism, single nucleotide, meat, middle aged, texas, female, male, urinary bladder, urinary bladder neoplasms, cooking, biomarkers, tumor
8 autores
- Jie Ming Lin🇺🇸The University of Texas MD Anderson Cancer Center
- Michele R. Forman🇺🇸The University of Texas MD Anderson Cancer Center
- Jianming Wang🇺🇸The University of Texas MD Anderson Cancer Center
- Herbert Barton Grossman🇺🇸The University of Texas MD Anderson Cancer Center
- Meng Chen🇺🇸The University of Texas MD Anderson Cancer Center
- Colin P. Dinney🇺🇸The University of Texas MD Anderson Cancer Center
- Ernest T. Hawk🇺🇸The University of Texas MD Anderson Cancer Center
- Xifeng Wu🇺🇸 · autor de correspondenciaThe University of Texas MD Anderson Cancer Center; In-Q-Tel
Resumen
El texto original del estudio, en el idioma en que se publicó.
We analyzed the association between meat intake, heterocyclic amines (HCAs) and bladder cancer (BC) risk in a large case-control study comprised of 884 BC cases and 878 healthy controls, recruited from 1999 to 2009. Epidemiologic and dietary data were collected via an in-person interview. Compared to the lowest quartile of red meat intake, the odds ratios (ORs) for the second, third and fourth quartiles were 1.17 (95% CI: 0.87-1.58), 1.47 (95% CI: 1.09-1.99) and 1.95 (95% CI: 1.41-2.68), respectively, (p-for trend <0.001). In a subset of participants with intakes of HCAs available, compared with those with the lowest quartile of intake, the ORs for the second, third and fourth quartiles were 1.47 (95% CI: 0.60-3.64), 2.58 (95% CI: 1.09-6.11) and 3.32 (95% CI: 1.37-8.01), respectively, (p for trend <0.001). In cumulative analysis of SNPs in the pathway, compared with subjects carrying 0-4 unfavorable genotypes, subjects carrying 5 and 6 or more unfavorable genotypes were at 1.60-fold (95% CI: 1.20-2.12) and 2.37-fold (95% CI: 1.82-3.10) increased risk, respectively. Moreover, subjects carrying six or more unfavorable genotypes and whose red meat intake was in the highest quartile were at 5.09-fold increased risk (95% CI: 2.89-8.96; p < 0.001). These results strongly support that high red meat intake, high intake of HCAs and carrying high number of unfavorable genotypes in the HCA metabolic pathways are associated with increased risk of BC in the study population.
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