Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials
Wang Q, Liang X, Wang L, Lu X, Huang J, Cao J, Li H, Gu D
Atherosclerosis · 164 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- National High Technology Research and Development Program of China
- Gobierno
- National Basic Research Program of China
- Subvenciones
- National Key Research and Development Program of China (2011CB503901)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-01-20 · Atherosclerosis · vol. 221 · número 2 · págs. 536–543
- Editorial
- Elsevier BV
- Citado
- 233 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- omega-3 fatty acids, dietary supplementation, endothelial function, flow-mediated dilation, endothelium-independent relaxation, cardiovascular risk, dose-response relationship
- MeSH
- endothelium, vascular, humans, cardiovascular diseases, fatty acids, omega-3, treatment outcome, regression analysis, evidence-based medicine, vasodilation, dose-response relationship, drug, time factors, dietary supplements, adolescent, adult, aged, middle aged, child, female, male, randomized controlled trials as topic, young adult
8 autores
- Qianqian Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Xiaohua Liang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Laiyuan Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Xiangfeng Lu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Jianfeng Huang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Jie Cao🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Hongfan Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Dongfeng Gu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Inverse association was reported between omega-3 fatty acids (FAs) supplementation and the risk of cardiovascular disease. Identifying the effect of omega-3 FAs on endothelial function may contribute to explain the association. We conducted a meta-analysis to assess the effect of omega-3 FAs supplementation on endothelial function, as measured by flow-mediated dilation (FMD) and endothelium-independent vasodilation (EIV).
Methods
Randomized placebo-controlled trials (RCTs) were identified from the databases of PubMed, EMBASE and Cochrane library by two investigators and the pooled effects were measured by weighted mean difference (WMD), together with 95% confidence intervals (CIs). Subgroup and meta-regression analyses were used to explore the source of between-study heterogeneity.
Results
Totally 16 eligible studies involving 901 participants were finally included in meta-analysis. Compared with placebo, omega-3 FAs supplementation significantly increased FMD by 2.30% (95% CI: 0.89-3.72%, P = 0.001), at a dose ranging from 0.45 to 4.5 g/d over a median of 56 days. Subgroup analyses suggested that the effect of omega-3 FAs on FMD might be modified by the health status of the participants or the dose of supplementation. Sensitivity analyses indicated that the protective effect of omega-3 on endothelial function was robust. No significant change in EIV was observed after omega-3 FAs supplementation (WMD: 0.57%; 95% CI: -0.88 to 2.01%; P = 0.442).
Conclusion
Supplementation of omega-3 fatty acids significantly improves the endothelial function without affecting endothelium-independent dilation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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