Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes
Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Kalayi A, Shariatzadeh N, Khalaji N, Gharavi A
Diabetes/metabolism research and reviews · 94 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Iran National Science Foundation
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-02-18 · Diabetes Metab Res Rev · vol. 28 · número 5 · págs. 424–430
- Editorial
- Wiley
- Citado
- 137 citas · más que el 99% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Palabras clave
- vitamin D supplementation, type 2 diabetes, systemic inflammation, doogh, yogurt, vitamin D3 fortification, C-reactive protein, serum amyloid A, interleukin-6, TNF-α, IL-10, 25-hydroxyvitamin D, glycemic control, cardiovascular risk, fat mass
- MeSH
- humans, diabetes mellitus, type 2, diabetes complications, inflammation, blood glucose, vitamin d, tumor necrosis factor-alpha, c-reactive protein, serum amyloid a protein, inflammation mediators, interleukins, prognosis, case-control studies, adult, middle aged, female, male, biomarkers
9 autores
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Tirang Reza Neyestani🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Abolghassem Djazayery🇮🇷Tehran University of Medical Sciences
- Mohammad Reza Eshraghian🇮🇷Tehran University of Medical Sciences
- Anahita Houshiarrad🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ali Kalayi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Nastaran Shariátzadeh🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Niloufar Khalaji🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- A’azam Gharavi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Both vitamin D deficiency and inflammation have been linked to cardiovascular disease, the major cause of death in diabetes. In this study, the effects of daily intake of vitamin D-fortified yoghourt drink (doogh) on systemic inflammatory biomarkers in subjects with type 2 diabetes (T2D) were investigated.
Subjects and methods
In this 12-week randomized controlled trial, T2D subjects received either plain doogh (PD; containing 170 mg calcium and no detectable vitamin D/250 mL, n(1) = 50) or vitamin D3-fortified doogh (FD; containing 170 mg calcium and 500 IU/250 mL, n(2) = 50) twice a day. Glycemic status, body fat mass and systemic inflammatory biomarkers including serum highly sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin(IL)-2, IL-6, IL-10 and tumour necrosis factor (TNF)-α were evaluated at the beginning and after the intervention. Data were expressed as either mean ± SD or median (interquartile range) whenever they had either normal or non-normal distribution, respectively.
Results
In the patients receiving the vitamin D fortified drink, compared with those receiving the unfortified drink, a significant increase in serum 25(OH)D was accompanied by significant changes in TNF-α (-57.9 (-264.6) versus +106.3 (683.2), p = 0.044), IL-6 (-6.3 (-69.2), p = 0.002), hsCRP (-0.39 (-1.50) versus +0.8 (1.52), p < 0.001), SAA (-14.2 ± 44.5 versus +5.6 ± 37.5 mg/L, p = 0.022) and IL-10 (+38.7 ± 157.0 versus -51.9 ± 165.2 ng/L, p = 0.013). The between-group differences of hsCRP, SAA and IL-6 changes remained significant even after controlling for changes quantitative insulin check index (p < 0.001, p < 0.001 and p = 0.009, respectively).
Conclusions
Improvement of vitamin D status of T2D subjects resulted in amelioration of the systemic inflammatory markers. This may have preventive implications against cardiovascular disease and other diabetic complications.
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