Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials
Wang H, Xia N, Yang Y, Peng DQ
Lipids in health and disease · 163 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2012-03-20 · Lipids Health Dis · vol. 11 · número 1 · pág. 42
- Editorial
- BioMed Central
- Citado
- 245 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Lipoproteins and Cardiovascular Health · Fatty Acid Research and Health
- Palabras clave
- vitamin D supplementation, plasma lipid profile, LDL cholesterol, total cholesterol, HDL cholesterol, triglycerides, hyperlipidemia, atherogenic lipids, vitamin D dose
- MeSH
- humans, lipids, vitamin d, treatment outcome, dyslipidemias, randomized controlled trials as topic, hypolipidemic agents
4 autores
- Hao Wang🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Ning Xia🇨🇳Central South University; Xiangya Hospital Central South University
- Yang Yang🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Daoquan Peng🇨🇳 · autor de correspondenciaCentral South University; Second Xiangya Hospital of Central South University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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