Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans
Castañer O, Covas MI, Khymenets O, Nyyssonen K, Konstantinidou V, Zunft HF, de la Torre R, Muñoz-Aguayo D, Vila J, Fitó M
The American journal of clinical nutrition · 80 citas
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Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-03-22 · Am J Clin Nutr · vol. 95 · número 5 · págs. 1238–1244
- Editorial
- Elsevier BV
- Citado
- 123 citas · más que el 97% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities · Fatty Acid Research and Health
- Palabras clave
- olive oil polyphenols, LDL oxidation, CD40 ligand, atherosclerosis, gene expression, MCP-1, IL23A, ADRB2, OLR1, ICAM-1, tyrosol, hydroxytyrosol, peripheral blood mononuclear cells, inflammation, cardiovascular health
- MeSH
- leukocytes, mononuclear, humans, phenylethyl alcohol, lipoproteins, ldl, plant oils, cd40 ligand, receptors, adrenergic, beta-2, antioxidants, cross-over studies, signal transduction, down-regulation, oxidation-reduction, oxidative stress, adult, middle aged, male, atherosclerosis, receptors, interleukin-8, young adult, polyphenols, olive oil
10 autores
- Olga Castañer🇪🇸Hospital Del Mar; Hospital del Mar Research Institute
- María‐Isabel Covas
- Olha Khymenets
- Kristiina Nyyssönen
- Valentini Konstantinidou
- Hans-Franz Zunft
- Rafael de la Torre
- Daniel Muñoz‐Aguayo
- Joan Vila
- Montserrat Fitó · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recently, the European Food Safety Authority approved a claim concerning the benefits of olive oil polyphenols for the protection of LDL from oxidation. Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression.
Objective
We assessed whether olive oil polyphenols could modulate the human in vivo expressions of atherosclerosis-related genes in which LDL oxidation is involved.
Design
In a randomized, crossover, controlled trial, 18 healthy European volunteers daily received 25 mL olive oil with a low polyphenol content (LPC: 2.7 mg/kg) or a high polyphenol content (HPC: 366 mg/kg) in intervention periods of 3 wk separated by 2-wk washout periods.
Results
Systemic LDL oxidation and monocyte chemoattractant protein 1 and the expression of proatherogenic genes in peripheral blood mononuclear cells [ie, CD40 ligand (CD40L), IL-23α subunit p19 (IL23A), adrenergic β-2 receptor (ADRB2), oxidized LDL (lectin-like) receptor 1 (OLR1), and IL-8 receptor-α (IL8RA)] decreased after the HPC intervention compared with after the LPC intervention. Random-effects linear regression analyses showed 1) a significant decrease in CD40, ADRB2, and IL8RA gene expression with the decrease of LDL oxidation and 2) a significant decrease in intercellular adhesion molecule 1 and OLR1 gene expression with increasing concentrations of tyrosol and hydroxytyrosol in urine.
Conclusions
In addition to reducing LDL oxidation, the intake of polyphenol-rich olive oil reduces CD40L gene expression, its downstream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans. These findings provide evidence that polyphenol-rich olive oil can act through molecular mechanisms to provide cardiovascular health benefits. This trial was registered at www.controlled-trials.com as ISRCTN09220811.
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