Influence of the slow infusion of a soybean oil emulsion on plasma cytokines and ex vivo T cell proliferation after an esophagectomy
Kagawa Y, Maeda T, Kato Y, Ueda I, Kudo T, Watanabe N, Kimura M, Minami S, Sakamoto T, Yamada H, Takagi M
JPEN. Journal of parenteral and enteral nutrition · 2 citas
Etiquetas de revisión
Alimentación controladaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Japan Society for the Promotion of Science
- Subvenciones
- Japan Society for the Promotion of Science (23590887); Japan Society for the Promotion of Science (22590138)
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-03-28 · JPEN J Parenter Enteral Nutr · vol. 37 · número 1 · págs. 123–128
- Editorial
- Wiley
- Citado
- 4 citas · más que el 17% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Hyperglycemia and glycemic control in critically ill and hospitalized patients · Enhanced Recovery After Surgery
- Palabras clave
- soybean oil emulsion, lipid emulsions, esophagectomy, esophageal cancer, immune response, plasma cytokines, T cell proliferation, MCP-1, interleukin-6, TNF-α, parenteral nutrition, rapid turnover proteins, postoperative immunosuppression
- MeSH
- esophagus, t-lymphocytes, humans, esophageal neoplasms, soybean oil, fat emulsions, intravenous, tumor necrosis factor-alpha, phytohemagglutinins, concanavalin a, interleukin-6, cytokines, parenteral nutrition, esophagectomy, cell proliferation, aged, middle aged, female, male, chemokine ccl2
11 autores
- Yoshiyuki Kagawa🇯🇵 · autor de correspondenciaShizuoka University; University of Shizuoka
- Toshio Maeda🇯🇵Shizuoka University; University of Shizuoka
- Yasuhiro Kato🇯🇵Shizuoka University; University of Shizuoka
- Iori Ueda🇯🇵Shizuoka University; University of Shizuoka
- Tomoko Kudo🇯🇵Shizuoka University; University of Shizuoka
- Naoe Watanabe🇯🇵Shizuoka University; University of Shizuoka
- Midori Kimura🇯🇵Shizuoka General Hospital
- Sato Minami🇯🇵Shizuoka General Hospital
- Tatsuichiro Sakamoto🇯🇵Shizuoka General Hospital
- Hiroshi Yamada🇯🇵Shizuoka University; University of Shizuoka
- Masakazu Takagi🇯🇵Shizuoka General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Lipid emulsions have been suggested to reduce immune responses, particularly in severely stressed patients. The authors investigated the influence of the slow intravenous infusion of a soybean oil-based lipid emulsion on some immune parameters in patients who had undergone an esophagectomy for esophageal cancer.
Methods
Thirty-two patients who had undergone an esophagectomy were randomly divided into a lipid emulsion (LPD)-treated group and a control group. All patients received parenteral feeding with a glucose-based solution. Patients in the LPD group received 100 mL of a 20% soybean oil emulsion for 7 days after the esophagectomy in addition to the glucose-based feeding. A slow infusion rate (0.09-0.12 g/kg/h) was adopted to take account of the intrinsic degradation of infused lipids. Immune responses were measured based on lymphocyte proliferation and serum concentrations of monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The authors also measured levels of rapid turnover proteins (ie, transferrin, prealbumin, and retinol-binding protein).
Results
Phytohemagglutinin- and concanavalin A-stimulated lymphocyte proliferation significantly decreased after the esophagectomy, but no significant difference was seen between the LPD and control groups. No significant difference in changes in plasma concentrations of MCP-1, IL-6 and TNF-α occurred between the 2 groups either. Plasma concentrations of rapid turnover proteins did not differ between the groups.
Conclusions
These results indicate that the lipid emulsion did not affect the immune parameters measured in patients who had undergone an esophagectomy when administered at a slow rate.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.