Effects of fish oil on VLDL triglyceride kinetics in humans
Harris WS, Connor WE, Illingworth DR, Rothrock DW, Foster DM
Journal of lipid research · 113 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-37940); National Heart, Lung, and Blood Institute (HL 25687); National Center for Research Resources (RR 334)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1990-09-01 · J Lipid Res · vol. 31 · número 9 · págs. 1549–1558
- Editorial
- Elsevier BV
- Citado
- 211 citas · más que el 99% de estudios similares · 10.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and disorders · Lipid metabolism and biosynthesis
- Palabras clave
- fish oil, omega-3 fatty acids, VLDL synthesis, VLDL catabolism, fractional catabolic rate, plasma triglycerides, hypotriglyceridemic effect, VLDL particle size, hypertriglyceridemia, dietary fat composition
- MeSH
- humans, hypertriglyceridemia, dietary fats, unsaturated, triglycerides, lipoproteins, vldl, fish oils, kinetics, male
5 autores
- WS Harris🇺🇸Oregon Health & Science University
- Connor We🇺🇸University of Kansas
- D. Roger Illingworth🇺🇸University of Kansas
- Douglas W. Rothrock🇺🇸University of Kansas
- DM Foster🇺🇸University of Kansas
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary n-3 fatty acids (FAs) found in fish oils markedly lower plasma triglyceride (TG) and very low density lipoprotein (VLDL) levels in both normal and hypertriglyceridemic subjects. The present study examined the mechanism of this effect. Ten subjects with widely different plasma triglyceride levels (82 to 1002 mg/dl) were fed metabolically controlled diets containing 20% fat. The control diet contained a blend of cocoa butter and peanut oil (P/S = 0.8). The test diet contained fish oil (P/S = 1.1) and provided 10-17 g of n-3 FAs per day (depending on calorie intake). After 3 to 5 weeks of each diet, the kinetics of VLDL-TG were determined over a 48-h period after the injection of [3H]glycerol. The fish oil diet reduced the VLDL-TG synthetic rate from 23 +/- 14.3 (mean +/- SD) to 12.6 +/- 7.5 mg/h per kg ideal weight (P less than 0.005) and increased the fractional catabolic rate (FCR) for VLDL-TG from 0.23 +/- 0.12 to 0.38 +/- 0.16 h -1 (P less than 0.005). At the same time, there was a 66% reduction of plasma triglyceride levels, resulting largely from a 78% decrease in VLDL-TG levels (398 +/- 317 to 87 +/- 77 mg/dl; P less than 0.005). There was a strong correlation (r = 0.83; P less than 0.01) between the change in synthetic rates and pool sizes, but there was no correlation (r = 0.24; NS) between changes in FCRs and pool sizes. The VLDL cholesterol: triglyceride ratio increased during the n-3 diet suggesting that smaller VLDL particles were present. These particles would be expected to leave the VLDL fraction more rapidly than larger particles producing a higher FCR. We conclude that the hypotriglyceridemic effect of fish oil appears to be caused primarily by an inhibition of very low density lipoprotein-triglyceride synthesis, but an additional, independent effect upon VLDL catabolism cannot be ruled out.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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