Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis
George PS, Pearson ER, Witham MD
Diabetic medicine : a journal of the British Diabetic Association · 237 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-04-04 · Diabet Med · vol. 29 · número 8 · págs. e142–50
- Editorial
- Wiley
- Citado
- 358 citas · más que el 99% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Management and Research · Diabetes Treatment and Management
- Palabras clave
- vitamin D supplementation, vitamin D analogs, glycemic control, insulin resistance, fasting blood glucose, HbA1c, impaired glucose tolerance, diabetes progression, microvascular complications, macrovascular complications, insulin and C-peptide
- MeSH
- humans, diabetes mellitus, type 1, diabetes mellitus, type 2, insulin resistance, vitamin d deficiency, diabetes complications, blood glucose, vitamins, vitamin d, fasting, dietary supplements, adult, aged, middle aged, female, male, randomized controlled trials as topic, glycated hemoglobin
3 autores
- Priya George🇬🇧University of Dundee; Ninewells Hospital
- Ewan R. Pearson🇬🇧University of Dundee; Ninewells Hospital
- Miles D. Witham🇬🇧 · autor de correspondenciaUniversity of Dundee; Ninewells Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.
Methods
Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitamin D or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin/C-peptide levels, micro- and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol.
Results
Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA(1c) or insulin resistance in those treated with vitamin D compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose (-0.32 mmol/l, 95%CI -0.57 to -0.07) and a small improvement in insulin resistance (standard mean difference -0.25, 95%CI -0.48 to -0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro- or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitamin D.
Conclusions
There is currently insufficient evidence of beneficial effect to recommend vitamin D supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.
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