Caffeine intake, smoking, and risk of Parkinson disease in men and women
Liu R, Guo X, Park Y, Huang X, Sinha R, Freedman ND, Hollenbeck AR, Blair A, Chen H
American journal of epidemiology · 120 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NCI NIH HHS
- Gobierno
- NINDS NIH HHS
- Gobierno
- Intramural NIH HHS
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (Z01-ES 101986); National Institute of Neurological Disorders and Stroke (R01‐NS060722); National Cancer Institute (Z01CP010196); National Institute of Neurological Disorders and Stroke (U01NS082151); National Institutes of Health (Z01-ES101986)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2012-04-13 · Am J Epidemiol · vol. 175 · número 11 · págs. 1200–1207
- Editorial
- Oxford University Press
- Citado
- 170 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Parkinson's Disease Mechanisms and Treatments · Coffee research and impacts · Dementia and Cognitive Impairment Research
- Palabras clave
- caffeine consumption, Parkinson's disease, smoking, disease risk, sex differences, AARP Diet and Health Study, neurodegenerative disease prevention
- MeSH
- humans, parkinson disease, caffeine, health surveys, multivariate analysis, logistic models, odds ratio, risk, follow-up studies, prospective studies, drinking behavior, smoking, sex factors, coffee, aged, middle aged, female, male, self report
9 autores
- R. Liu🇺🇸National Institute of Environmental Health Sciences
- Xiaohui Guo🇺🇸Westat (United States); National Institute of Environmental Health Sciences
- Yikyung Park🇺🇸National Institutes of Health; National Institute of Environmental Health Sciences
- Xuemei Huang🇺🇸National Institute of Environmental Health Sciences
- Rashmi R. Sinha🇺🇸National Institutes of Health; National Institute of Environmental Health Sciences
- Neal D. Freedman🇺🇸National Institutes of Health; National Institute of Environmental Health Sciences
- A. R. Hollenbeck🇺🇸AARP; National Institute of Environmental Health Sciences
- Aaron E. Blair🇺🇸National Institutes of Health; National Institute of Environmental Health Sciences
- Honglei Chen🇺🇸 · autor de correspondenciaNational Institutes of Health; National Institute of Environmental Health Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
The authors prospectively examined whether caffeine intake was associated with lower risk of Parkinson disease (PD) in both men and women among 304,980 participants in the National Institutes of Health-AARP Diet and Health Study and whether smoking affected this relation. Multivariate odds ratios and 95% confidence intervals were derived from logistic regression models. Higher caffeine intake as assessed in 1995-1996 was monotonically associated with lower PD risk (diagnosed in 2000-2006) in both men and women. After adjustment for age, race, and physical activity, the odds ratio comparing the highest quintile of caffeine intake with the lowest was 0.75 (95% confidence interval: 0.60, 0.94; P(trend) = 0.005) for men and 0.60 (95% confidence interval: 0.39, 0.91; P(trend) = 0.005) for women. Further adjustment for duration of smoking and analyses carried out among never smokers showed similar results. A joint analysis with smoking suggested that smoking and caffeine may act independently in relation to PD risk. Finally, the authors conducted a meta-analysis of prospective studies and confirmed that caffeine intake was inversely associated with PD risk in both men and women. These findings suggest no gender difference in the relation between caffeine and PD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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