Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults
Tong H, Rappold AG, Diaz-Sanchez D, Steck SE, Berntsen J, Cascio WE, Devlin RB, Samet JM
Environmental health perspectives · 81 citas
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Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Environmental Protection Agency
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of North Carolina at Chapel Hill
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Center for Research Resources (RR00046); National Center for Research Resources (M01RR000046); National Institutes of Health (RR-00046)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2012-04-19 · Environ Health Perspect · vol. 120 · número 7 · págs. 952–957
- Editorial
- National Institute of Environmental Health Sciences
- Citado
- 104 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · PUBLIC-DOMAIN
- Áreas de investigación
- Air Quality and Health Impacts · Fatty Acid Research and Health · Heart Rate Variability and Autonomic Control
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, particulate matter, air pollution, cardiovascular effects, heart rate variability, QT interval, plasma lipids, triglycerides, VLDL, olive oil, middle-aged adults
- MeSH
- heart, humans, fatty acids, omega-3, fish oils, heart rate, dietary supplements, middle aged, female, male, particulate matter
8 autores
- Haiyan Tong🇺🇸Environmental Protection Agency
- Ana Grohovac Rappold🇺🇸Environmental Protection Agency
- David Díaz-Sánchez🇺🇸Environmental Protection Agency
- Susan E. Steck🇺🇸University of South Carolina
- Jon H. Berntsen
- Wayne E. Cascio🇺🇸Environmental Protection Agency
- Robert B. Devlin🇺🇸Environmental Protection Agency
- James M. Samet🇺🇸Environmental Protection Agency
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Air pollution exposure has been associated with adverse cardiovascular health effects. Findings of a recent epidemiological study suggested that omega-3 fatty acid (fish oil) supplementation blunted cardiac responses to air pollution exposure.
Objectives
We conducted a randomized, controlled exposure study to evaluate the efficacy of fish oil supplements in attenuating adverse cardiac effects of exposure to concentrated ambient fine and ultrafine particulate matter (CAP).
Methods
Twenty-nine healthy middle-aged participants (mean, 58 ± 1 years of age) were supplemented in a randomized, double-blinded manner with 3 g/day of either fish oil or olive oil for 4 weeks before sequential chamber exposure to filtered air and CAP (mean mass concentration 278 ± 19 µg/m3) for 2 hr. Cardiac responses were assessed by comparing time and frequency domain changes in heart rate variability (HRV) and electrocardiographic repolarization changes measured before, immediately after, and 20 hr after exposure. Changes in plasma lipids were also evaluated at these time points.
Results
Fish oil supplementation appeared to attenuate CAP-induced reductions in high-frequency/low-frequency ratio, as well as elevations in normalized low-frequency HRV and prolongation of the QT interval corrected for heart rate (QTc). Very low-density lipoprotein and triglyceride concentrations increased significantly immediately after exposure to CAP in participants supplemented with olive oil, but not in those supplemented with fish oil.
Conclusions
Exposure of healthy middle-aged adults to CAP for 2 hr induced acute cardiac and lipid changes after supplementation with olive oil, but not fish oil. Our findings suggest that omega-3 fatty acid supplements offer protection against the adverse cardiac and lipid effects associated with air pollution exposure.
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