Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies
Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ
Diabetologia · 188 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Research UK
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- Medical Research Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-04-14 · Diabetologia · vol. 55 · número 8 · págs. 2173–2182
- Editorial
- Springer Science+Business Media
- Citado
- 261 citas · más que el 98% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, type 2 diabetes, diabetes risk, circulating vitamin D levels, EPIC-Norfolk cohort, inverse association, vitamin D supplementation, VDR polymorphisms
- MeSH
- humans, diabetes mellitus, type 2, vitamin d, incidence, risk factors, cohort studies, prospective studies, adult, aged, middle aged, england, female, male, white people
7 autores
- Nita G. Forouhi🇬🇧 · autor de correspondenciaAddenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
- Ziyan Ye🇬🇧Addenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
- Anna P. Rickard🇬🇧Addenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
- Kay‐Tee Khaw🇬🇧University of Cambridge
- Robert Luben🇬🇧University of Cambridge
- Claudia Langenberg🇬🇧Addenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
- Nicholas J. Wareham🇬🇧Addenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims/hypothesis
Epidemiological evidence is suggestive, but limited, for an association between circulating 25-hydroxyvitamin D (25[OH]D) and risk of type 2 diabetes. We conducted a systematic review and meta-analysis that included new data from previously unpublished studies.
Methods
Using a nested case-cohort design in the European Prospective Investigation into Cancer (EPIC)-Norfolk study, we identified a random subcohort and incident type 2 diabetes cases occurring between baseline (1993-1997) and 2006. In the Ely prospective study we identified incident type 2 diabetes cases between 1990 and 2003. We conducted a systematic review of prospective studies on 25(OH)D and type 2 diabetes published in MEDLINE or EMBASE until 31 January 2012, and performed a random-effects meta-analysis combining available evidence with results from the EPIC-Norfolk and Ely studies.
Results
In EPIC-Norfolk, baseline 25(OH)D was lower among incident type 2 diabetes cases (mean [SD] 61.6 [22.4] nmol/l; n=621) vs non-case subcohort participants (mean 65.3 [23.9] nmol/l; n=826). There was an inverse association between baseline 25(OH)D and incident type 2 diabetes in multivariable-adjusted analyses: HR (95% CI) 0.66 (0.45, 0.97), 0.53 (0.34, 0.82), 0.50 (0.32, 0.76), p trend <0.001, comparing consecutive increasing 25(OH)D quartiles with the lowest. In Ely, 37 incident type 2 diabetes cases were identified among 777 participants. In meta-analysis, the combined RR of type 2 diabetes comparing the highest with lowest quartile of 25(OH)D was 0.59 (0.52, 0.67), with little heterogeneity (I (2) =2.7%, p=0.42) between the 11 studies included (3,612 cases and 55,713 non-cases).
Conclusions/interpretation
These findings demonstrate an inverse association between circulating 25(OH)D and incident type 2 diabetes. However, causal inference should be addressed through adequately dosed randomised trials of vitamin D supplementation or genetic Mendelian randomisation experiments.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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