Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial
Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P
International journal of food sciences and nutrition · 133 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-04-26 · Int J Food Sci Nutr · vol. 63 · número 7 · págs. 767–771
- Editorial
- Taylor & Francis
- Citado
- 209 citas · más que el 94% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Natural Antidiabetic Agents Studies · Phytochemicals and Antioxidant Activities
- Palabras clave
- Insulin resistance, Type 2 diabetes, Internal medicine, Medicine, Placebo, Insulin, Diabetes mellitus, Endocrinology, Randomized controlled trial, Homeostasis, Double blind, Gastroenterology
- MeSH
- humans, brassica, plant shoots, diabetes mellitus, type 2, hyperglycemia, hyperinsulinism, insulin resistance, isothiocyanates, sulfoxides, insulin, blood glucose, antioxidants, double-blind method, patient compliance, dietary supplements, adult, middle aged, patient dropouts, iran, female, male
6 autores
- Zahra Bahadoran🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Maryam Tohidi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Pantea Nazeri🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Mahya Mehran🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Fereidoun Azizi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
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