Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial
Milte CM, Parletta N, Buckley JD, Coates AM, Young RM, Howe PR
Nutrition (Burbank, Los Angeles County, Calif.) · 90 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-04-25 · Nutrition · vol. 28 · número 6 · págs. 670–677
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 12% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Aquaculture Nutrition and Growth
- Palabras clave
- attention deficit hyperactivity disorder, eicosapentaenoic acid, docosahexaenoic acid, omega-3 polyunsaturated fatty acids, fatty acid supplementation, safflower oil, erythrocyte fatty acids, literacy, word reading, spelling, oppositional behavior, hyperactivity, learning difficulties, children
- MeSH
- erythrocytes, humans, dietary fats, docosahexaenoic acids, eicosapentaenoic acid, safflower oil, treatment outcome, severity of illness index, child behavior, parents, cognition, learning, attention, attention deficit disorder with hyperactivity, dietary supplements, reading, child, australia, female, male, learning disabilities
6 autores
- Catherine M. Milte🇦🇺University of South Australia
- Natalie Parletta🇦🇺 · autor de correspondenciaUniversity of South Australia
- Jonathan David Buckley🇦🇺University of South Australia
- Alison Mary Coates🇦🇺University of South Australia
- Ross McD. Young🇦🇺Queensland University of Technology
- Peter R.C. Howe
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effects of an eicosapentaenoic acid (EPA)-rich oil and a docosahexaenoic acid (DHA)-rich oil versus an ω-6 polyunsaturated fatty acid-rich safflower oil (control) on literacy and behavior in children with attention-deficit/hyperactivity disorder (ADHD) in a randomized controlled trial.
Methods
Supplements rich in EPA, DHA, or safflower oil were randomly allocated for 4 mo to 90 Australian children 7 to 12 y old with ADHD symptoms higher than the 90th percentile on the Conners Rating Scales. The effect of supplementation on cognition, literacy, and parent-rated behavior was assessed by linear mixed modeling. Pearson correlations determined associations between the changes in outcome measurements and the erythrocyte fatty acid content (percentage of total) from baseline to 4 mo.
Results
There were no significant differences between the supplement groups in the primary outcomes after 4 mo. However, the erythrocyte fatty acid profiles indicated that an increased proportion of DHA was associated with improved word reading (r = 0.394) and lower parent ratings of oppositional behavior (r = 0.392). These effects were more evident in a subgroup of 17 children with learning difficulties: an increased erythrocyte DHA was associated with improved word reading (r = 0.683), improved spelling (r = 0.556), an improved ability to divide attention (r = 0.676), and lower parent ratings of oppositional behavior (r = 0.777), hyperactivity (r = 0.702), restlessness (r = 0.705), and overall ADHD symptoms (r = 0.665).
Conclusion
Increases in erythrocyte ω-3 polyunsaturated fatty acids, specifically DHA, may improve literacy and behavior in children with ADHD. The greatest benefit may be observed in children who have comorbid learning difficulties.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.