Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia
Zhou SJ, Yelland L, McPhee AJ, Quinlivan J, Gibson RA, Makrides M
The American journal of clinical nutrition · 96 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-05-02 · Am J Clin Nutr · vol. 95 · número 6 · págs. 1378–1384
- Editorial
- Elsevier BV
- Citado
- 133 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Pregnancy and preeclampsia studies · Gestational Diabetes Research and Management
- Palabras clave
- fish oil supplementation, docosahexaenoic acid, n-3 long-chain polyunsaturated fatty acids, gestational diabetes mellitus, preeclampsia, pregnancy, perinatal outcomes, perinatal death, neonatal seizures, birth weight
- MeSH
- humans, seizures, diabetes, gestational, pre-eclampsia, infant, newborn, diseases, dietary fats, fatty acids, omega-3, docosahexaenoic acids, fish oils, plant oils, pregnancy outcome, incidence, prevalence, maternal mortality, risk, double-blind method, pregnancy, dietary supplements, adult, infant, newborn, female
6 autores
- Shao Jia Zhou🇦🇺Women's & Children's Health Research Institute
- Lisa Nicole Yelland
- Andy McPhee
- Julie A. Quinlivan
- Robert Alan Gibson
- Maria Makrides
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is uncertainty regarding the efficacy of increasing n-3 long-chain PUFA (LCPUFA) intake during pregnancy in reducing the risk of gestational diabetes mellitus (GDM) and preeclampsia.
Objectives
The objective was to determine whether n-3 LCPUFA supplementation in pregnancy reduces the incidence of GDM or preeclampsia. A secondary objective was to assess the effect of n-3 LCPUFA supplementation on perinatal complications.
Design
This was a double-blind, multicenter randomized control trial-the DHA to Optimize Mother Infant Outcome (DOMInO) trial. Pregnant women (n = 2399) of <21 wk gestation were randomly assigned to receive DHA-enriched fish oil (800 mg/d) or vegetable oil capsules without DHA from trial entry to birth. The presence of GDM or preeclampsia was assessed through a blinded audit of medical records. Birth outcomes and prenatal complications were also assessed.
Results
The overall incidences of GDM and preeclampsia were 8% and 5%, respectively, based on clinical diagnosis. The RR of GDM was 0.97 (95% CI: 0.74, 1.27) and of preeclampsia was 0.87 (95% CI: 0.60, 1.25), and they did not differ significantly between the groups. Birth weight, length, and head circumference z scores also did not differ between the groups. There were 12 perinatal deaths and 5 neonatal convulsions in the control group compared with 3 perinatal deaths and no neonatal convulsions in the DHA group (P = 0.03 in both cases).
Conclusion
DHA supplementation of 800 mg/d in the second half of pregnancy does not reduce the risk of GDM or preeclampsia. Whether supplementation reduces the risk of perinatal death and neonatal convulsions requires further investigation. The DOMInO trial was registered with the Australian New Zealand Clinical Trials Registry as TRN12605000569606.
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