Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults
Cashman KD, Seamans KM, Lucey AJ, Stöcklin E, Weber P, Kiely M, Hill TR
The American journal of clinical nutrition · 146 citas
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- Resultado principal
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Publicación
- Publicado
- 2012-05-03 · Am J Clin Nutr · vol. 95 · número 6 · págs. 1350–1356
- Editorial
- Elsevier BV
- Citado
- 204 citas · más que el 98% de estudios similares · 8.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Vitamin K Research Studies
- Palabras clave
- 25-hydroxyvitamin D3, vitamin D3, 25-hydroxyvitamin D, vitamin D supplementation, relative potency, conversion factors, older adults, winter, serum calcium, hypercalcemia, food composition tables, vitamin D intake, vitamin D deficiency prevention
- MeSH
- humans, vitamin d deficiency, calcium, cholecalciferol, calcifediol, vitamins, vitamin d, diet, administration, oral, double-blind method, sunlight, seasons, dietary supplements, middle aged, female, male
7 autores
- Kevin D. Cashman🇮🇪University College Cork
- Kelly M. Seamans
- Alice J. Lucey
- Elisabeth Stöcklin
- Peter Weber
- Mairead E Kiely
- Tom R. Hill
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The relative potency of 25-hydroxyvitamin D3 to vitamin D3 needs to be better defined so that food-composition tables can better reflect the true vitamin D nutritive value of certain foods.
Objective
We performed a randomized, controlled intervention study in apparently healthy, free-living adults to investigate whether the intake of 25-hydroxyvitamin D3 is 5 times more potent in raising serum 25-hydroxyvitamin D [25(OH)D] during winter compared with an equivalent amount of vitamin D3.
Design
A randomized, placebo-controlled, double-blind intervention study was conducted in adults aged ≥50 y (n = 56) who consumed a placebo, 20 μg vitamin D3, or 7 or 20 μg 25-hydroxyvitamin D3 daily throughout 10 wk of winter. Serum 25(OH)D was measured by using an enzyme-linked immunoassay, and serum albumin-corrected calcium (S-Ca) was assessed colorimetrically at the baseline, midpoint, and endpoint of the study.
Results
The mean (±SD) increases (per microgram of vitamin D compound) in serum 25(OH)D concentrations over baseline after 10 wk of supplementation were 0.96 ± 0.62, 4.02 ± 1.27, and 4.77 ± 1.04 nmol · L(-1) · μg intake(-1) for the 20-μg vitamin D3/d and 7- and 20-μg 25-hydroxyvitamin D3/d groups, respectively. A comparison of the 7- and 20-μg 25-hydroxyvitamin D3/d groups with the 20-μg vitamin D3/d group yielded conversion factors of 4.2 and 5, respectively. There was no effect of treatment on S-Ca concentrations and no incidence of hypercalcemia (S-Ca >2.6 nmol/L).
Conclusions
Each microgram of orally consumed 25-hydroxyvitamin D3 was about 5 times more effective in raising serum 25(OH)D in older adults in winter than an equivalent amount of vitamin D3. This conversion factor could be used in food-compositional tables for relevant foods. This study was registered at clinicaltrials.gov as NCT01398202.
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