Red and processed meat intake and risk of colorectal adenomas: a meta-analysis of observational studies
Xu X, Yu E, Gao X, Song N, Liu L, Wei X, Zhang W, Fu C
International journal of cancer · 56 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-05-03 · Int J Cancer · vol. 132 · número 2 · págs. 437–448
- Editorial
- Wiley
- Citado
- 72 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Colorectal Cancer Screening and Detection · Nutritional Studies and Diet
- Palabras clave
- Red meat, Medicine, Meta-analysis, Relative risk, Confounding, Confidence interval, Colorectal adenoma, Observational study, Internal medicine, Cohort study, Colorectal cancer, Animal science, Cancer, Biology, Pathology
- MeSH
- animals, cattle, deer, sheep, swine, adenoma, colorectal neoplasms, risk, regression analysis, case-control studies, cross-sectional studies, meat products
8 autores
- Xiaodong Xu🇨🇳Second Military Medical University; Changhai Hospital
- Enda Yu🇨🇳🇩🇪Second Military Medical University; X-Fab (Germany); Changhai Hospital
- Xianhua Gao🇨🇳🇩🇪Second Military Medical University; X-Fab (Germany); Changhai Hospital
- Ning Song🇨🇳Second Military Medical University; Changhai Hospital
- Lianjie Liu🇨🇳Second Military Medical University; Changhai Hospital
- Xubiao Wei🇨🇳Second Military Medical University; Changhai Hospital
- Wei Zhang🇨🇳Second Military Medical University; Changhai Hospital
- Chuangang Fu🇨🇳 · autor de correspondenciaSecond Military Medical University; Changhai Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Inconsistent results regarding the association between red and processed meat intake and the risk of colorectal adenoma (CRA), the precursor of colorectal cancer (CRC), have been reported. To provide a quantitative assessment of this association, we summarized the evidence from observational studies. Relevant studies were identified in MEDLINE and EMBASE until December 31, 2011. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were pooled with a random-effects model. Between-study heterogeneity was assessed using the Cochran's Q and I(2) statistics. A total of 21 studies (16 case-control studies and five cohort/nested case-control studies) were included in this meta-analysis. The SRRs of CRA were 1.36 (95% CI = 1.17-1.58) for every 100 g/day increase in red meat intake, and 1.24 (95% CI = 1.12-1.36) for the highest versus the lowest level of red meat intake. Nonlinear dose-response meta-analysis indicated that CRA risk increased approximately linearly with increasing intake of red meat up to ~ 90 g/day, where the curve reached its plateau. Subgrouped analyses revealed that the increased risk of CRA with intake of red meat was independent of geographic locations, design and confounders. The SRRs of CRA was 1.28 (95% CI = 1.03-1.60) for per 50 g/day increase in processed meat intake, and 1.17 (95% CI = 1.08-1.26) for the highest versus the lowest level of processed meat intake. Increased intake of red and processed meat is associated with significantly increased risk of CRA.
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