Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates
Uauy RD, Birch DG, Birch EE, Tyson JE, Hoffman DR
Pediatric research · 354 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Universidad u hospital
- Research Committee, Aristotle University of Thessaloniki
- Gobierno
- National Eye Institute
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Gobierno
- NEI NIH HHS
- Subvenciones
- National Eye Institute (EY05236); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD22830); National Eye Institute (EY-05235)
Según 6 financiadores declarados.
Publicación
- Publicado
- 1990-11-01 · Pediatr Res · vol. 28 · número 5 · págs. 485–492
- Editorial
- Springer Nature
- Citado
- 574 citas · más que el 100% de estudios similares · 29.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 4 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Birth, Development, and Health
- Palabras clave
- omega-3 fatty acids, very low birth weight infants, retinal function, electroretinogram, rod photoreceptors, cone function, long-chain polyunsaturated fatty acids, docosahexaenoic acid, breast milk, infant formula, dietary supplementation, marine oils, plasma fatty acids, n-6/n-3 ratio, retinal development
- MeSH
- retina, milk, human, humans, lipids, fatty acids, omega-3, electroretinography, double-blind method, nutritional requirements, infant, newborn, infant, low birth weight, infant nutritional physiological phenomena
5 autores
- Ricardo D. Uauy🇺🇸The University of Texas Southwestern Medical Center
- David G. Birch🇺🇸Retina Foundation of the Southwest; The University of Texas Southwestern Medical Center
- Eileen E. Birch🇺🇸Retina Foundation of the Southwest; The University of Texas Southwestern Medical Center
- Jon E. Tyson🇺🇸The University of Texas Southwestern Medical Center
- Dennis R. Hoffman🇺🇸The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Retinal function was assessed by electroretinogram in 32 neonates randomly assigned to formulas of different omega-3 fatty acid content and in 10 infants fed human milk. All neonates had a birth weight of 1000-1500 g and were fed study diets from d 10 to 45 or discharge. Group A received formula containing predominantly 18:2 omega-6. Group B received a balanced mix of 18:2 omega-6 and 18:3 omega-3. Group C was given a formula containing both essential fatty acids and supplemented with marine oil to provide 22:6 omega-3 content similar to that of human milk. The fatty acid composition of plasma and red blood cell (RBC) lipids were similar for all groups on entry but marked diet-induced differences were found after feeding the study diets. Group C was comparable to the human milk-fed group, but group A had lower 22:6 omega-3 and omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in plasma and RBC membranes. Cone function was not affected by dietary essential fatty acids. Rod electroretinogram thresholds were significantly higher for group A relative to the human milk-fed group and group C and significantly correlated with RBC omega-3 LCPUFA (r = -0.63, p less than 0.0001); 44% of the variance could be explained by RBC and plasma omega-3 LCPUFA content.(ABSTRACT TRUNCATED AT 250 WORDS)
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