Successful improvement of frequency and symptoms of premature complexes after oral magnesium administration
Falco CN, Grupi C, Sosa E, Scanavacca M, Hachul D, Lara S, Sacilotto L, Pisani CF, Ramires JA, Darrieux F
Arquivos brasileiros de cardiologia · 8 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-05-12 · Arq Bras Cardiol · vol. 98 · número 6 · págs. 480–487
- Editorial
- Sociedade Brasileira de Cardiologia (SBC)
- Citado
- 12 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC
- Áreas de investigación
- Magnesium in Health and Disease · Cardiac electrophysiology and arrhythmias · Cardiac Arrhythmias and Treatments
- Palabras clave
- magnesium supplementation, premature ventricular contractions, ventricular arrhythmias, arrhythmia frequency, symptom improvement, oral magnesium, Holter monitoring
- MeSH
- humans, atrial premature complexes, ventricular premature complexes, pyrrolidonecarboxylic acid, treatment outcome, statistics, nonparametric, double-blind method, placebo effect, time factors, adolescent, adult, aged, middle aged, female, male, young adult
10 autores
- Cristina Nádja M. Lima De Falco🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- César Grupi🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Eduardo Sosa🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Maurício Scanavacca🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Denise Tessariol HACHUL🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Sissy Lara🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Luciana Sacilotto🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Cristiano Faria Pisani🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- José Antônio Franchini Ramires🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Francisco Darrieux🇧🇷Universidade de São Paulo; Instituto do Coração - HCFMUSP
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Premature ventricular and supraventricular complexes (PVC and PsVC) are frequent and often symptomatic. The magnesium (Mg) ion plays a role in the physiology of cell membranes and cardiac rhythm.
Objective
We evaluated whether the administration of Mg Pidolate (MgP) in patients with PVC and PsVC is superior to placebo (P) in improving symptoms and arrhythmia frequency.
Methods
Randomized double-blind study with 60 consecutive symptomatic patients with more than 240 PVC or PsVC on 24-hour Holter monitoring who were selected to receive placebo (P) or MgP. To evaluate symptom improvement, a categorical and a specific questionnaire for symptoms related to PVC and PsVC was made. Improvement in premature complex density (PCD) per hour was considered significant if percentage reduction was >70% after treatment. The dose of MgP was 3.0 g/day for 30 days, equivalent to 260 mg of Mg element. Any patient had structural heart disease or renal failure.
Results
Of the 60 patients, 33 were female (55%). Ages ranged from 16 to 70 years old. In the MgP group, 76.6% of patients had a PCD reduction >70%, 10% of them >50% and only 13.4% <50%. In the P group, 40% showed slight improvement, <30%, in the PC frequency (p < 0.001). Symptom improvement was achieved in 93.3% of patients in the MgP group, compared with only 16.7% in the P group (p < 0.001).
Conclusion
Oral Mg supplementation decreases PCD, resulting in symptom improvement.
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