A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk
Gepner AD, Ramamurthy R, Krueger DC, Korcarz CE, Binkley N, Stein JH
PloS one · 141 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- School of Medicine and Public Health, University of Wisconsin-Madison
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NIH Clinical Center
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Center for Research Resources (UL1RR025011); National Heart, Lung, and Blood Institute (K23 HL094760)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2012-05-07 · PLoS One · vol. 7 · número 5 · pág. e36617
- Editorial
- Public Library of Science
- Citado
- 184 citas · más que el 100% de estudios similares · 17.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- vitamin D supplementation, vitamin D3, cardiovascular risk, postmenopausal women, endothelial function, flow-mediated dilation, arterial stiffness, pulse wave velocity, augmentation index, C-reactive protein, inflammation, 25-hydroxyvitamin D, body mass index, blood pressure, glucose
- MeSH
- brachial artery, humans, cardiovascular diseases, blood glucose, vitamin d, body mass index, risk factors, prospective studies, double-blind method, postmenopause, blood pressure, heart rate, vasodilation, dietary supplements, aged, middle aged, female
6 autores
- Adam D. Gepner🇺🇸University of Wisconsin–Madison
- Rekha Ramamurthy🇺🇸University of Wisconsin–Madison
- Diane C. Krueger🇺🇸University of Wisconsin–Madison
- Claudia E. Korcarz🇺🇸University of Wisconsin–Madison
- Neil Binkley🇺🇸University of Wisconsin–Madison
- James H. Stein🇺🇸 · autor de correspondenciaUniversity of Wisconsin–Madison
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D (VitD) supplementation has been advocated for cardiovascular risk reduction; however, supporting data are sparse. The objective of this study was to determine whether VitD supplementation reduces cardiovascular risk. Subjects in this prospective, randomized, double-blind, placebo-controlled trial of post-menopausal women with serum 25-hydroxyvitamin D concentrations >10 and <60 ng/mL were randomized to Vitamin D3 2500 IU or placebo, daily for 4 months. Primary endpoints were changes in brachial artery flow-mediated vasodilation (FMD), carotid-femoral pulse wave velocity (PWV), and aortic augmentation index (AIx). The 114 subjects were mean (standard deviation) 63.9 (3.0) years old with a 25-hydroxyvitamin D level of 31.3 (10.6) ng/mL. Low VitD (<30 ng/mL) was present in 47% and was associated with higher body-mass index, systolic blood pressure, glucose, CRP, and lower FMD (all p<0.05). After 4 months, 25-hydroxyvitamin D levels increased by 15.7 (9.3) ng/mL on vitamin D3 vs. -0.2 (6.1) ng/mL on placebo (p<0.001). There were no significant differences between groups in changes in FMD (0.3 [3.4] vs. 0.3 [2.6] %, p = 0.77), PWV (0.00 [1.06] vs. 0.05 [0.92] m/s, p = 0.65), AIx (2.7 [6.3] vs. 0.9 [5.6] %, p = 0.10), or CRP (0.3 [1.9] vs. 0.3 [4.2] mg/L, p = 0.97). Multivariable models showed no significant interactions between treatment group and low VitD status (<30 ng/mL) for changes in FMD (p = 0.65), PWV (p = 0.93), AIx (p = 0.97), or CRP (p = 0.26). In conclusion, VitD supplementation did not improve endothelial function, arterial stiffness, or inflammation. These observations do not support use of VitD supplementation to reduce cardiovascular disease risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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