Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies
Gerber M
The British journal of nutrition · 150 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-05-17 · Br J Nutr · vol. 107 · número S2 · págs. S228–S239
- Editorial
- Cambridge University Press
- Citado
- 214 citas · más que el 100% de estudios similares · 22.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, polyunsaturated fatty acids, cancer risk, cancer prevention, adjuvant therapy, n-3 long-chain polyunsaturated fatty acids, alpha-linolenic acid, fish consumption, colorectal cancer, prostate cancer, breast cancer, lung cancer, carcinogenesis
- MeSH
- animals, fishes, humans, neoplasms, breast neoplasms, colorectal neoplasms, lung neoplasms, prostatic neoplasms, fatty acids, omega-3, alpha-linolenic acid, anticarcinogenic agents, diet, female, male
1 autor
- M Gerber🇫🇷 · autor de correspondenciaInstitut de Recherche en Cancérologie de Montpellier
Resumen
El texto original del estudio, en el idioma en que se publicó.
Experimental models showed consistently a modulation of carcinogenesis by omega 3 polyunsaturated fatty acids (ω3 PUFA). Fish intake is often described as part of a beneficial dietary pattern. However, observational epidemiological studies on the relationship between ω3 PUFA reported conflicting results. The objective of this systematic review is to determine whether there exists any progress in the evaluation of the causal relationship between dietary ω3 PUFA and cancers since the previous FAO/OMS expert consultation and whether it is possible to propose preventive and/or adjuvant therapeutic recommendations. Prospective and case-control observational studies published since 2007 and meeting validity criteria were considered together with RCT. Experimental studies are mentioned to provide for biological plausibility. When evaluating the level of evidence, a portfolio approach was used, weighted by a hierarchy giving higher importance to prospective studies followed by RCT if any. There is a probable level of evidence that ALA per se is neither a risk factor nor a beneficial factor with regards to cancers. Observational studies on colorectal, prostate and breast cancers only provided limited evidence suggesting a possible role of LC-ω3PUFA in cancer prevention because insufficient homogeneity of the observations. Explanation for heterogeneity might be the inherent difficulties associated with epidemiology (confounding and dietary pattern context, measurement error, level of intake, genetic polymorphism). The role of LC-ω3PUFA as adjuvant, might be considered of possible use, in view of the latest RCT on lung cancers even if RCT on other cancers still need to be undertaken.
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