A systematic review of omega-3 fatty acids and osteoporosis
Orchard TS, Pan X, Cheek F, Ing SW, Jackson RD
The British journal of nutrition · 79 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- WHI NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- PHS HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- U.S. Department of Health and Human Services (42129‐32); U.S. Department of Health and Human Services (42107-26); U.S. Department of Health and Human Services (32108‐9); National Heart, Lung, and Blood Institute (32100‐2); U.S. Department of Health and Human Services (32118-32119); National Heart, Lung, and Blood Institute (32118‐32119); U.S. Department of Health and Human Services (32115); National Heart, Lung, and Blood Institute (N01‐WH‐22110); National Heart, Lung, and Blood Institute (32118); National Institutes of Health (32122); National Center for Research Resources (UL1RR025755); National Institutes of Health (N01 WH044221); National Institutes of Health (32108‐9); U.S. Public Health Service (44221); National Center for Advancing Translational Sciences (UL1TR000090); National Institutes of Health (42107–26); National Heart, Lung, and Blood Institute (42107‐26); National Heart, Lung, and Blood Institute (32119); National Heart, Lung, and Blood Institute (24152); National Heart, Lung, and Blood Institute (32105–6); U.S. Department of Health and Human Services (32100‐2); U.S. Public Health Service (32122); National Institutes of Health (32118-32119); U.S. Public Health Service (24152); National Institutes of Health (44221); National Institutes of Health (32115); U.S. Public Health Service (42107-26); National Institutes of Health (32100‐2); U.S. Public Health Service (42129-32); National Institutes of Health (N01 WH024152); National Heart, Lung, and Blood Institute (32108‐9); U.S. Public Health Service (32118-32119); National Heart, Lung, and Blood Institute (32115); National Heart, Lung, and Blood Institute (N01 WH032118); U.S. Department of Health and Human Services (44221); U.S. Public Health Service (32100-2); National Heart, Lung, and Blood Institute (N01 WH042107); National Heart, Lung, and Blood Institute (42129‐32); U.S. Department of Health and Human Services (32105‐6); U.S. Public Health Service (32105-6); U.S. Department of Health and Human Services (32122); U.S. Department of Health and Human Services (24152); U.S. Department of Health and Human Services (N01-WH-2-2110); National Heart, Lung, and Blood Institute (32122); National Heart, Lung, and Blood Institute (N01 WH032105); National Institutes of Health (N01-WH-2-2110); U.S. Public Health Service (32108-9); U.S. Public Health Service (32111-13); U.S. Public Health Service (32115); National Institutes of Health (24152); National Heart, Lung, and Blood Institute (44221); National Institutes of Health (N01 WH032100); National Institutes of Health (N01 WH032108); National Institutes of Health (N01 WH022110); National Institutes of Health (N01 WH042129); National Institutes of Health (N01 WH032115); National Institutes of Health (N01 WH032111); National Institutes of Health (N01 WH032122); National Institutes of Health (32105-6)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2012-05-17 · Br J Nutr · vol. 107 · número S2 · págs. S253–S260
- Editorial
- Cambridge University Press
- Citado
- 114 citas · más que el 70% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Bone health and osteoporosis research · Vitamin D Research Studies
- Palabras clave
- omega-3 fatty acids, osteoporosis, bone mineral density, fracture risk, bone turnover markers, calcium supplementation, dietary supplementation, skeletal health, randomized controlled trials
- MeSH
- bone and bones, humans, osteoporosis, bone resorption, fatty acids, omega-3, diet, osteogenesis, bone density, dietary supplements, fractures, bone
5 autores
- Tonya Orchard🇺🇸The Ohio State University
- Xueliang Jeff Pan🇺🇸The Ohio State University
- Fern M. Cheek🇺🇸The Ohio State University
- Steven Wai Ing🇺🇸The Ohio State University
- Rebecca D. Jackson🇺🇸 · autor de correspondenciaThe Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Some epidemiological evidence suggests that diets high in omega 3 fatty acids (n-3 FAs) may be beneficial for skeletal health. The aim of this systematic review was to determine if randomized controlled trials (RCTs) support a positive effect of n-3 FAs on osteoporosis. A systematic search was performed in PubMed and EMBASE databases. We included RCTs with skeletal outcomes conducted in adults or children (> = 1 year old) using n-3 FA fortified foods, diets or supplements alone or in combination with other vitamins/minerals, versus placebo. Primary outcomes were incident fracture at any site and bone mineral density (BMD) in g/cm2. Secondary outcomes included bone formation or resorption markers and bone turnover regulators. A total of 10 RCTs met inclusion criteria. Effect sizes with 95 % confidence intervals were estimated to compare studies across various treatments and outcome measures. No pooled analysis was completed due to heterogeneity of studies and small sample sizes. No RCTs included fracture as an outcome. Four studies reported significant favorable effects of n-3 FA on BMD or bone turnover markers. Of these, three delivered n-3 FA in combination with high calcium foods or supplements. Five studies reported no differences in outcomes between n-3 FA intervention and control groups; one study included insufficient data for effect size estimation. Strong conclusions regarding n-3 FAs and bone disease are limited due to the small number and modest sample sizes of RCTs, however, it appears that any potential benefit of n-3 FA on skeletal health may be enhanced by concurrent administration of calcium.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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