The nonskeletal effects of vitamin D: an Endocrine Society scientific statement
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS
Endocrine reviews · 491 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- National Institutes of Health
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIAMS NIH HHS
- Gobierno
- BLRD VA
- Gobierno
- CIHR
- Gobierno
- NCI NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIAID NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R24 DK092759); U.S. Department of Veterans Affairs (I01 BX001066); National Cancer Institute (U01CA138962); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR050023); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21 AR056885); National Institute of Diabetes and Digestive and Kidney Diseases (DK092759); National Center for Research Resources (UL1-RR-033176); National Institute of Diabetes and Digestive and Kidney Diseases (DK 46974); National Institutes of Health (UL1TR000124); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK046974); National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32 AR059033); National Institute of Allergy and Infectious Diseases (R01AI073539); National Cancer Institute (CA13896); Canadian Institutes of Health Research (MOP‐84253)
Según 17 financiadores declarados.
Publicación
- Publicado
- 2012-05-17 · Endocr Rev · vol. 33 · número 3 · págs. 456–492
- Editorial
- Oxford University Press
- Citado
- 765 citas · más que el 100% de estudios similares · 44.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 592 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D, vitamin D receptor, 25-hydroxyvitamin D, vitamin D supplementation, maternal and child health, cardiovascular disease, metabolic disorders, cancer, musculoskeletal disorders, chronic disease prevention
- MeSH
- skin, animals, humans, mice, rats, neoplasms, musculoskeletal diseases, cardiovascular diseases, diabetes mellitus, type 2, obesity, vitamin d, receptors, calcitriol, accidental falls, fetal development, pregnancy, quality of life, dietary supplements, female, male, randomized controlled trials as topic
8 autores
- Clifford james Rosen🇺🇸Tufts University
- John S. Adams🇺🇸University of California, Los Angeles; Orthopaedic Hospital
- Daniel D. Bikle🇺🇸University of California, San Francisco
- Dennis M. Black🇺🇸University of California, San Francisco
- Marie B. Demay🇺🇸Harvard University; Massachusetts General Hospital
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Mohammad Hassan Murad🇺🇸Mayo Clinic
- Christopher S. Kovács🇨🇦Memorial University of Newfoundland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders. In this paper, we review both the basic and clinical aspects of vitamin D in relation to nonskeletal organ systems. We begin by focusing on the molecular aspects of vitamin D, primarily by examining the structure and function of the vitamin D receptor. This is followed by a systematic review according to tissue type of the inherent biological plausibility, the strength of the observational data, and the levels of evidence that support or refute an association between vitamin D levels or supplementation and maternal/child health as well as various disease states. Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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