Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial
Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R
Brain, behavior, and immunity · 177 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCI NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIA NIH HHS
- Gobierno
- NIH
- Subvenciones
- National Center for Research Resources (UL1RR025755); National Cancer Institute (CA16058); National Institute on Aging (R01AG029562); National Center for Research Resources (M01 RR000034); National Cancer Institute (P30CA016058); National Institute on Aging (AG029562)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2012-05-26 · Brain Behav Immun · vol. 26 · número 6 · págs. 988–995
- Editorial
- Elsevier BV
- Citado
- 233 citas · más que el 99% de estudios similares · 15.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Tryptophan and brain disorders · Nutritional Studies and Diet
- Palabras clave
- omega-3 polyunsaturated fatty acids, dietary supplementation, inflammation, interleukin-6, TNF-α, depressive symptoms, overweight, sedentary lifestyle, middle-aged and older adults, serum cytokines
- MeSH
- humans, body weight, fatty acids, omega-3, fatty acids, tumor necrosis factor-alpha, anti-inflammatory agents, non-steroidal, interleukin-6, treatment outcome, sample size, depression, health behavior, dose-response relationship, drug, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male, overweight, waist circumference, sedentary behavior
6 autores
- Janice K. Kiecolt‐Glaser🇺🇸 · autor de correspondenciaThe Ohio State University
- Martha Ann Belury🇺🇸The Ohio State University
- Rebecca Andridge🇺🇸The Ohio State University
- William B. Malarkey🇺🇸The Ohio State University
- Beom Seuk Hwang🇺🇸The Ohio State University
- Ronald Glaser🇺🇸The Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies have linked lower levels of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) with inflammation and depression. This study was designed to determine whether n-3 supplementation would decrease serum cytokine production and depressive symptoms in 138 healthy middle-aged and older adults (average age=51.04, SD=7.76) who were sedentary and overweight (average BMI=30.59, SD=4.50). This three-arm randomized, placebo-controlled, double-blind 4-month trial compared responses to (1) 2.5 g/d n-3 PUFAs, or (2) 1.25 g/d n-3 PUFAs, or (3) placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Serum interleukin-6 decreased by 10% and 12% in our low and high dose n-3 groups, respectively, compared to a 36% increase in the placebo group. Similarly, low and high dose n-3 groups showed modest 0.2% and -2.3% changes in serum tumor necrosis factor alpha, compared to a 12% increase in the control group. Depressive symptoms were quite low at baseline and did not change significantly in response to supplementation. Our data suggest that n-3 PUFAs can reduce inflammation in overweight, sedentary middle-aged and older adults, and thus could have broad health benefits. These data provide a window into the ways in which the n-3 PUFAs may impact disease initiation, progression, and resolution. ClinicalTrials.gov identifier: NCT00385723.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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