Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial
Gontijo-Amaral C, Guimarães EV, Camargos P
The American journal of clinical nutrition · 16 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-05-31 · Am J Clin Nutr · vol. 96 · número 1 · págs. 50–56
- Editorial
- Elsevier BV
- Citado
- 24 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cystic Fibrosis Research Advances · Magnesium in Health and Disease · Trace Elements in Health
- Palabras clave
- cystic fibrosis, oral magnesium supplementation, hypomagnesemia, respiratory muscle strength, maximal inspiratory pressure, maximal expiratory pressure, Shwachman-Kulczycki score, urinary magnesium, children and adolescents, micronutrient therapy
- MeSH
- respiratory muscles, humans, cystic fibrosis, magnesium, organometallic compounds, glycine, respiratory function tests, severity of illness index, follow-up studies, cross-over studies, double-blind method, dietary supplements, adolescent, adult, child, female, male, muscle strength, young adult
3 autores
- Clésio Gontijo-Amaral🇧🇷Universidade Federal de Minas Gerais
- Elizabet Vilar Guimarães
- Paulo Augusto Moreira Camargos
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium is one of the most important minerals in the body. Although some studies reported that patients with cystic fibrosis (CF) lack magnesium, no international study has assessed the importance of oral magnesium supplementation in CF patients.
Objective
We prospectively investigated the long-term effect of oral magnesium supplementation on respiratory muscle strength by using manuvacuometry and the Shwachman-Kulczycki (SK) score among children and adolescents with CF.
Design
This double-blind, randomized, placebo-controlled crossover study included 44 CF patients (aged 7-19 y; 20 males) who were randomly assigned to receive magnesium (n = 22; 300 mg/d) or placebo (n = 22) for 8 wk with a 4-wk washout period between trials. All patients were undergoing conventional treatment of CF. The experimental protocol included clinical evaluation, assessment of urinary concentration of magnesium, and manuvacuometric measurements [maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP)]. MIP was the primary outcome.
Results
Urinary magnesium increased after the administration of magnesium (change: 36.38 mg/d after magnesium compared with 0.72 mg/d after placebo; P < 0.001). Moreover, MIP and MEP significantly improved only after magnesium administration (change in MIP: 11% predicted after magnesium compared with 0.5% predicted after placebo; change in MEP: 11.9% predicted after magnesium compared with 0.8% predicted after placebo; P < 0.001 for both). Magnesium administration had a beneficial effect on clinical variables assessed by the SK score (change: 4.48 points after magnesium compared with -1.30 points after placebo; P < 0.001).
Conclusion
Oral magnesium supplementation helped improve both the SK score and respiratory muscle strength in pediatric patients with CF.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.