Diets containing pistachios reduce systolic blood pressure and peripheral vascular responses to stress in adults with dyslipidemia
West SG, Gebauer SK, Kay CD, Bagshaw DM, Savastano DM, Diefenbach C, Kris-Etherton PM
Hypertension (Dallas, Tex. : 1979) · 43 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Pennsylvania State University
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR000127); National Center for Research Resources (M01-RR-010732)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2012-06-05 · Hypertension · vol. 60 · número 1 · págs. 58–63
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 56 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Blood pressure, Saturated fat, Medicine, Crossover study, Heart rate, Internal medicine, Endocrinology, Calorie, Vascular resistance, Animal science, Cardiology, Cholesterol, Biology, Placebo
- MeSH
- brachial artery, humans, pistacia, ultrasonography, cardiac output, diet, fat-restricted, fasting, cross-over studies, blood pressure, heart rate, vascular resistance, dose-response relationship, drug, adult, dyslipidemias, stress, physiological, outcome assessment, health care
7 autores
- Sheila G. West🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Sarah K Gebauer🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Colin D. Kay🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Deborah Maddox Bagshaw🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- David M. Savastano🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Christopher Diefenbach🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Penny M. Kris‐Etherton🇬🇧🇺🇸University of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nut consumption reduces cardiovascular risk, and reductions in blood pressure and peripheral vascular resistance may be important mediators of this relationship. We evaluated effects of pistachios on flow-mediated dilation and blood pressure response to acute stress. Twenty-eight adults with dyslipidemia completed a randomized, crossover, controlled-feeding study. All of the meals were provided and calories were controlled. After 2 weeks on a typical Western diet (35% total fat and 11% saturated fat), test diets were presented in counterbalanced order for 4 weeks each, a low-fat control diet (25% total fat and 8% saturated fat), a diet containing 10% of energy from pistachios (on average, 1 serving per day; 30% total fat and 8% saturated fat), and a diet containing 20% of energy from pistachios (on average, 2 servings per day, 34% total fat and 8% saturated fat). None of the resting hemodynamic measures significantly differed from pretreatment values. When resting and stress levels were included in the repeated-measures analysis, average reductions in systolic blood pressure were greater after the diet containing 1 serving per day versus 2 servings per day of pistachios (mean change in systolic blood pressure, -4.8 vs -2.4 mm Hg, respectively; P<0.05). After the higher dose, there were significant reductions in peripheral resistance (-62.1 dyne · s × cm(-5)) and heart rate (-3 bpm) versus the control diet (P<0.0001). These changes were partially offset by increases in cardiac output. There was no effect of diet on fasting flow-mediated dilation. Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers.
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