Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis
Djoussé L, Akinkuolie AO, Wu JH, Ding EL, Gaziano JM
Clinical nutrition (Edinburgh, Scotland) · 121 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL09246S1); National Heart, Lung, and Blood Institute (F32HL009246); National Heart, Lung, and Blood Institute (R01HL092946); National Heart, Lung, and Blood Institute (T32HL007575); National Heart, Lung, and Blood Institute (1R01 HL092946)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2012-06-06 · Clin Nutr · vol. 31 · número 6 · págs. 846–853
- Editorial
- Elsevier BV
- Citado
- 169 citas · más que el 75% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Heart Failure Treatment and Management
- Palabras clave
- fish consumption, omega-3 fatty acids, heart failure, incident heart failure risk, marine omega-3 fatty acids, dietary intake, cardiovascular disease prevention
- MeSH
- animals, fishes, humans, fatty acids, omega-3, incidence, risk factors, seafood, heart failure
5 autores
- Luc Djoussé🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- Akintunde O. Akinkuolie🇺🇸Brigham and Women's Hospital
- Jason H. Y. Wu🇺🇸🇦🇺Harvard University; The University of Western Australia
- Eric L. Ding🇺🇸Harvard University
- J. Michael Gaziano🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
While marine omega-3 fatty acids have been associated with a lower mortality in heart failure patients, data on omega-3 and incident heart failure are inconsistent. We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis.
Methods
We identified relevant studies by searching MEDLINE and EMBASE databases up to August 31, 2011 without restrictions and by reviewing reference lists from retrieved articles.
Results
A total of 176,441 subjects and 5480 incident cases of heart failure from 7 prospective studies were included in this analysis. Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05. There was no evidence for heterogeneity across studies of fish consumption (I(2) = 8%). In contrast, there was modest heterogeneity for omega-3 fatty acid analysis (I(2) = 44%). Lastly, there was no evidence for publication bias.
Conclusions
This meta-analysis is consistent with a lower risk of heart failure with intake of marine omega-3 fatty acids. These observational findings should be confirmed in a large randomized trial.
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