A systematic review: influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration
Autier P, Gandini S, Mullie P
The Journal of clinical endocrinology and metabolism · 92 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-06-15 · J Clin Endocrinol Metab · vol. 97 · número 8 · págs. 2606–2613
- Editorial
- Oxford University Press
- Citado
- 144 citas · más que el 88% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, 25-hydroxyvitamin D, vitamin D3, vitamin D2, calcium supplementation, older adults, serum vitamin D levels, dose-response relationship, baseline vitamin D status
- MeSH
- humans, vitamin d, dietary supplements, aged, middle aged, female, randomized controlled trials as topic
3 autores
- Philippe Autier🇫🇷 · autor de correspondenciaInternational Prevention Research Institute
- Sara Gandini🇮🇹European Institute of Oncology
- Patrick Mullie🇫🇷International Prevention Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Few studies in subjects over 50 yr of age have evaluated the influence of variable doses of vitamin D supplementation on serum 25-hydroxyvitamin D levels.
Objective
We performed a meta-analysis of changes in circulating 25-hydroxyvitamin D level associated with vitamin D supplementation in Caucasian subjects over 50 yr old.
Data sources
We conducted a systematic search in literature databases and in references of past reviews.
Study selection
Randomized placebo or open-label trials that evaluated the influence of vitamin D supplementation on clinical outcomes were included in the study.
Data extraction
We reviewed trial characteristics and serum 25-hydroxyvitamin D concentrations at baseline and during the trial.
Data synthesis
Seventy-six trials published from 1984 to March 2011 included 6207 subjects allocated to 101 intervention groups that tested supplement doses ranging from 5 to 250 μg/d (median, 20 μg/d). For similar doses, trials could obtain increases in 25-hydroxyvitamin D three to four times lower than other trials. A meta-regression showed that in the absence of concomitant use of calcium supplements, the average increase in serum 25-hydroxyvitamin D concentrations was 0.78 ng/ml (1.95 nmol/liter) per microgram of vitamin D3 supplement per day. Compared to the vitamin D3, the vitamin D2 was associated with significantly lower increases (P = 0.03). Concomitant use of calcium supplementation and high 25-hydroxyvitamin D concentration at baseline was nonsignificantly associated with lower increases in 25-hydroxyvitamin D concentrations.
Conclusions
Dietary recommendations and randomized trials on vitamin D supplementation should evaluate whether increases in circulating 25-hydroxyvitamin D levels match expectations--for instance, the average increases obtained by trials on vitamin D3 without concomitant calcium supplements.
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