Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial
Höfling DB, Chavantes MC, Juliano AG, Cerri GG, Knobel M, Yoshimura EM, Chammas MC
Lasers in medical science · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-06-20 · Lasers Med Sci · vol. 28 · número 3 · págs. 743–753
- Editorial
- Springer Science+Business Media
- Citado
- 36 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Thyroid Disorders and Treatments · Biofield Effects and Biophysics
- Palabras clave
- low-level laser therapy, chronic autoimmune thyroiditis, hypothyroidism, thyroid peroxidase antibodies, thyroglobulin antibodies, thyroid echogenicity, thyroid autoimmunity, 830 nm laser
- MeSH
- thyroid gland, humans, hypothyroidism, thyroxine, autoantibodies, ultrasonography, adult, middle aged, female, male, hashimoto disease, low-level light therapy
7 autores
- Danilo Bianchini Höfling🇧🇷 · autor de correspondenciaUniversidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Maria Cristina Chavantes🇧🇷Universidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Instituto do Coração - HCFMUSP
- Adriana Gonçalves Juliano🇧🇷Universidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Giovanni Guido Cerri🇧🇷Universidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Meyer Knobel🇧🇷Universidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Elisabeth Mateus Yoshimura🇧🇷Universidade de São Paulo
- Maria Cristina Chammas🇧🇷Universidade de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic autoimmune thyroiditis (CAT) is the most common cause of acquired hypothyroidism, which requires lifelong levothyroxine replacement therapy. Currently, no effective therapy is available for CAT. Thus, the objective of this study was to evaluate the efficacy of low-level laser therapy (LLLT) in patients with CAT-induced hypothyroidism by testing thyroid function, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), and ultrasonographic echogenicity. A randomized, placebo-controlled trial with a 9-month follow-up was conducted from 2006 to 2009. Forty-three patients with a history of levothyroxine therapy for CAT-induced hypothyroidism were randomly assigned to receive either 10 sessions of LLLT (830 nm, output power of 50 mW, and fluence of 707 J/cm(2); L group, n=23) or 10 sessions of a placebo treatment (P group, n=20). The levothyroxine was suspended 30 days after the LLLT or placebo procedures. Thyroid function was estimated by the levothyroxine dose required to achieve normal concentrations of T3, T4, free-T4 (fT4), and thyrotropin after 9 months of postlevothyroxine withdrawal. Autoimmunity was assessed by measuring the TPOAb and TgAb levels. A quantitative computerized echogenicity analysis was performed pre- and 30 days postintervention. The results showed a significant difference in the mean levothyroxine dose required to treat the hypothyroidism between the L group (38.59 ± 20.22 μg/day) and the P group (106.88 ± 22.90 μg/day, P<0.001). Lower TPOAb (P=0.043) and greater echogenicity (P<0.001) were also noted in the L group. No TgAb difference was observed. These findings suggest that LLLT was effective at improving thyroid function, promoting reduced TPOAb-mediated autoimmunity and increasing thyroid echogenicity in patients with CAT hypothyroidism.
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