Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
Riso P, Klimis-Zacas D, Del Bo' C, Martini D, Campolo J, Vendrame S, Møller P, Loft S, De Maria R, Porrini M
European journal of nutrition · 181 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-06-25 · Eur J Nutr · vol. 52 · número 3 · págs. 949–961
- Editorial
- Springer Science+Business Media
- Citado
- 259 citas · más que el 99% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Bioactive Compounds in Plants · Pomegranate: compositions and health benefits
- Palabras clave
- Oxidative stress, Vaccinium, Inflammation, Medicine, Endothelial dysfunction, Traditional medicine, Food science, Biology, Botany, Internal medicine
- MeSH
- endothelium, vascular, humans, fruit, cardiovascular diseases, dna damage, cinnamates, pyrimidines, flavonoids, purines, antioxidants, risk factors, cross-over studies, oxidation-reduction, oxidative stress, beverages, adult, middle aged, italy, male, biomarkers, blueberry plants
10 autores
- Patrizia Riso🇮🇹 · autor de correspondenciaUniversity of Milan
- Dorothy J. Klimis‐Zacas🇺🇸University of Maine
- Cristian Del Bo’🇮🇹University of Milan
- Daniela Martini🇮🇹University of Milan
- Jonica Campolo🇮🇹Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda; Istituto di Fisiologia Clinica
- Stefano Vendrame🇺🇸University of Maine
- Peter Möller🇩🇰University of Copenhagen
- Steffen H Loft🇩🇰University of Copenhagen
- Renata De Maria🇮🇹Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda; Istituto di Fisiologia Clinica
- Marisa Porrini🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Wild blueberries (WB) (Vaccinium angustifolium) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease.
Methods
Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m²) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed.
Results
Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p ≤ 0.01) and the levels of H₂O₂-induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study.
Conclusions
In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function.
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