Assessment of Helicobacter pylori eradication by virgin olive oil
Castro M, Romero C, de Castro A, Vargas J, Medina E, Millán R, Brenes M
Helicobacter · 18 citas
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Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Junta de Andalucía
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-04-17 · Helicobacter · vol. 17 · número 4 · págs. 305–311
- Editorial
- Wiley
- Citado
- 34 citas · más que el 87% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Helicobacter pylori-related gastroenterology studies · Consumer Attitudes and Food Labeling · Hibiscus Plant Research Studies
- Palabras clave
- Helicobacter pylori, Olive oil, Medicine, Urea breath test, Traditional medicine, Helicobacter pylori infection, Internal medicine, Food science, Biology
- MeSH
- humans, helicobacter pylori, helicobacter infections, plant oils, anti-bacterial agents, pilot projects, adult, aged, middle aged, female, male, young adult, olive oil
7 autores
- Manuel Castro de Moura🇪🇸Hospital Universitario de Valme
- Concepción Romero🇪🇸 · autor de correspondenciaInstituto de la Grasa
- Antonio de Castro🇪🇸Instituto de la Grasa
- Julio Vargas🇪🇸Hospital Universitario de Valme
- Eduardo Medina🇪🇸Instituto de la Grasa
- Raquel Millán🇪🇸Hospital Universitario de Valme
- Manuel Brenes🇪🇸Instituto de la Grasa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A recent study conducted by Medina et al. disclosed that virgin olive oil has a bactericidal effect in vitro against Helicobacter pylori because of its contents of certain phenolic compounds with dialdehydic structures. We carried out two clinical trials to evaluate the effect of virgin olive oil on H. pylori-infected individuals.
Materials and methods
Two different pilot studies were performed with 60 H. pylori-infected adults. In the first study, thirty subjects who tested positive for H. pylori received 30 g of washed virgin olive oil for 14 days, and after 1 month, the patients took 30 g of unwashed virgin olive oil for another 14 days. In a second study, a group of 30 subjects received 30 g of a different virgin olive oil for 14 days. Helicobacter pylori-infection status was checked by the urea breath test.
Results
Helicobacter pylori was eradicated in 8 of 30 individuals when microorganism status was checked after 4-6 weeks from the first clinical intervention although 12 of 30 individuals did not show H. pylori infection at 24-72 hour of the last oil dose. Eradication rates were 27 and 40% by intention to treat and per protocol, respectively. Moreover, only 3 of 30 individuals were H. pylori negative after 4-6 weeks from the second clinical intervention but 5 of 30 were negative at 24-72 hour of the last oil dose. Eradication rates were 10 and 11% by intention to treat and per protocol, respectively. It must also be noted that 13 subjects withdrew from the studies because of taste and nausea drawbacks.
Conclusions
The administration of virgin olive oil showed moderate effectiveness in eradicating H. pylori. Further studies are needed to confirm these findings, especially with longer periods, different administration conditions, and several types of olive oils.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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