Magnesium intake and incidence of stroke: meta-analysis of cohort studies
Nie ZL, Wang ZM, Zhou B, Tang ZP, Wang SK
Nutrition, metabolism, and cardiovascular diseases : NMCD · 27 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-07-11 · Nutr Metab Cardiovasc Dis · vol. 23 · número 3 · págs. 169–176
- Editorial
- Elsevier BV
- Citado
- 46 citas · más que el 35% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, stroke, ischemic stroke, stroke incidence, stroke mortality, dose-response relationship, stroke risk reduction
- MeSH
- humans, magnesium, incidence, risk factors, dose-response relationship, drug, stroke
5 autores
- Zhenlin Nie🇨🇳Nanjing First Hospital; Nanjing Medical University
- Z.-M. Wang🇨🇳Jiangsu Province Hospital
- Bo Zhou🇨🇳Nanjing Tech University
- Zheng Tang🇨🇳Nanjing First Hospital; Nanjing Medical University
- S.-K. Wang🇨🇳 · autor de correspondenciaNanjing First Hospital; Nanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Prospective cohort studies are inconsistent regarding the association between magnesium intake and the risk of stroke. The objective was to perform a meta-analysis to summarise the relationship between magnesium intake and risk of stroke in observational studies.
Methods and results
We searched the PubMed and EMBASE databases for studies conducted from 1966 through August 2011. Prospective studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between magnesium intake and the risk of total stroke incidence or mortality were included. Data were independently abstracted by two investigators using a standardised protocol. Study-specific risk estimates were combined by using a random effects model. A total of eight studies, with 8367 stroke cases among 304,551 participants, were included in the meta-analysis. The summary RR indicated a significant association between the highest magnesium intake and reduced risk of total stroke (summary RR: 0.89; 95% CI: 0.82, 0.97); our dose-response analysis showed a borderline inverse association between magnesium intake and total stroke risk (an increment of 100 mg day(-1); summary RR: 0.98; 95% CI: 0.95, 1.00). Subgroup analyses suggested a significant inverse association between highest magnesium intake and the risk of ischaemic stroke (summary RR: 0.88; 95% CI: 0.80, 0.98).
Conclusion
The present meta-analysis of prospective cohorts suggests that higher magnesium intake is associated with reduced risk of total and ischaemic stroke. However, well-designed randomised controlled trials are needed to draw a definitive conclusion.
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