Oral magnesium lozenge reduces postoperative sore throat: a randomized, prospective, placebo-controlled study
Borazan H, Kececioglu A, Okesli S, Otelcioglu S
Anesthesiology · 52 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-07-14 · Anesthesiology · vol. 117 · número 3 · págs. 512–518
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 77 citas · más que el 95% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Airway Management and Intubation Techniques · Anesthesia and Pain Management · Anesthesia and Sedative Agents
- Palabras clave
- postoperative sore throat, orotracheal intubation, NMDA receptor antagonism, pain modulation, orthopedic surgery, preoperative analgesia
- MeSH
- humans, pharyngitis, inflammation, postoperative complications, magnesium, receptors, n-methyl-d-aspartate, administration, oral, prospective studies, double-blind method, biological availability, adult, middle aged, female, male
4 autores
- Hale Borazan
- Ahmet Keçecioğlu
- Selmın Ökeslı🇹🇷Necmettin Erbakan University
- Şeref Otelcioğlu🇹🇷Necmettin Erbakan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Postoperative sore throat (POST) is an undesirable complaint after orotracheal intubation. Magnesium is a noncompetitive N-methyl-D-aspartate receptor antagonist thought to be involved in the modulation of pain. The present study aimed to investigate the effect of preoperative administration of oral magnesium lozenge on POST.
Methods
Seventy patients undergoing orthopedic surgery were randomly allocated into two groups, to either receive placebo (control) or magnesium lozenges (magnesium) to be dissolved by sucking 30 min preoperatively. Patients were assessed for incidence and severity (four-point scale, 0-3) of POST at 0, 2, 4, and 24 h postoperatively. The primary outcome was sore throat at 4 h after surgery. The secondary outcome was the severity of POST at four evaluation time-points postoperatively.
Results
The incidence of POST at 4 h was higher in control group than in magnesium group (95% CI: 26%, 14-42%; P=0.032). The highest incidence of POST occurred at the second hour after surgery, with the rate of 23% in the magnesium group and 57% in the control group (95% CI: 34%, 20-51%; P=0.007). The severity of POST was significantly lower in the magnesium group at 0 (P=0.007) and 2 h (P=0.002). The incidences of POST at 0 and 24 h and severity scores at 4 and 24 h were not significantly different between the groups.
Conclusions
The administration of magnesium lozenge 30 min preoperatively is effective to reduce both incidence and severity of POST in the immediate postoperative period.
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