Effect of vitamin D and inhaled corticosteroid treatment on lung function in children
Wu AC, Tantisira K, Li L, Fuhlbrigge AL, Weiss ST, Litonjua A, Childhood Asthma Management Program Research Group
American journal of respiratory and critical care medicine · 101 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Brigham and Women's Hospital
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (N01-HR-16045); National Heart, Lung, and Blood Institute (M01RR02719); National Heart, Lung, and Blood Institute (U01 HL075420); National Center for Research Resources (M01RR02719-14); National Center for Research Resources (M01 RR000036); National Center for Research Resources (M01RR-00051); National Center for Research Resources (M01RR002719); National Heart, Lung, and Blood Institute (U01HL075419); National Heart, Lung, and Blood Institute (N01-HR-16051); National Heart, Lung, and Blood Institute (U01-HL065899); National Heart, Lung, and Blood Institute (16045); National Center for Research Resources (M01RR000051); National Heart, Lung, and Blood Institute (U01HL075416); National Heart, Lung, and Blood Institute (N01 HR016044); National Heart, Lung, and Blood Institute (K08HL088046); National Heart, Lung, and Blood Institute (R21HL089842); National Heart, Lung, and Blood Institute (16046); National Heart, Lung, and Blood Institute (N01-HR16048); National Heart, Lung, and Blood Institute (N01-HR-16046); National Heart, Lung, and Blood Institute (N01HR16047); National Heart, Lung, and Blood Institute (NO1-HR-16044); National Heart, Lung, and Blood Institute (N01-HR16044); National Heart, Lung, and Blood Institute (U01HL075417); National Heart, Lung, and Blood Institute (U01HL075407); National Heart, Lung, and Blood Institute (U01HL075232); National Heart, Lung, and Blood Institute (U01HL075409); National Heart, Lung, and Blood Institute (U01HL075408); National Heart, Lung, and Blood Institute (U01HL075415); National Heart, Lung, and Blood Institute (N01HR16049); National Center for Research Resources (M01 RR0099718-24); National Heart, Lung, and Blood Institute (N01HR16052); National Heart, Lung, and Blood Institute (N01-HR16050); National Center for Research Resources (RR.00036); National Heart, Lung, and Blood Institute (M01RR00051)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2012-07-14 · Am J Respir Crit Care Med · vol. 186 · número 6 · págs. 508–513
- Editorial
- American Thoracic Society
- Citado
- 137 citas · más que el 99% de estudios similares · 15.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Adrenal Hormones and Disorders
- Palabras clave
- vitamin D deficiency, vitamin D insufficiency, inhaled corticosteroids, childhood asthma, lung function, FEV1, bronchodilator response, methacholine responsiveness, airway responsiveness, 25-hydroxyvitamin D, persistent asthma
- MeSH
- humans, asthma, vitamin d deficiency, nedocromil, budesonide, vitamin d, respiratory function tests, spirometry, monitoring, physiologic, treatment outcome, administration, inhalation, severity of illness index, risk assessment, follow-up studies, prospective studies, reference values, child, child, preschool, female, male
6 autores
- Ann Chen Wu🇺🇸Boston Children's Hospital; Harvard University; Harvard Pilgrim Health Care
- Kelan G. Tantisira🇺🇸Brigham and Women's Hospital; Harvard University
- Lingling Li🇺🇸Harvard University; Harvard Pilgrim Health Care
- Anne L. Fuhlbrigge🇺🇸Harvard University
- Scott T. Weiss🇺🇸Brigham and Women's Hospital; Harvard University
- Augusto A. Litonjua🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control.
Objectives
To assess the effect of vitamin D levels on prebronchodilator FEV(1), bronchodilator response, and responsiveness to methacholine (PC(20), provocative concentration of methacholine producing a 20% decline in FEV(1)) in patients with asthma treated with inhaled corticosteroids.
Methods
We measured 25-hydroxyvitamin D levels in the serum of children with persistent asthma at the time of enrollment in the Childhood Asthma Management Program. We divided subjects into the vitamin D sufficiency (>30 ng/ml), insufficiency (20-30 ng/ml), and deficiency (<20 ng/ml) groups. Covariates included age, treatment, sex, body mass index, race, history of emergency department visits, hospitalizations, and season that vitamin D specimen was drawn. Our main outcome measures were change in prebronchodilator FEV(1), bronchodilator response, and PC(20) from enrollment to 8-12 months.
Measurements and main results
Of the 1,024 subjects, 663 (65%) were vitamin D sufficient, 260 (25%) were insufficient, and 101 (10%) were deficient. Vitamin D-deficient subjects were more likely to be older, African American, and have a higher body mass index compared with the vitamin D-sufficient and insufficient subjects. In the inhaled corticosteroid treatment group, prebronchodilator FEV(1) increased from randomization to 12 months by 140 ml in the vitamin D-deficient group and prebronchodilator FEV(1) increased by 330 ml in the vitamin D insufficiency group and by 290 ml in the vitamin D sufficiency group (P = 0.0072), in adjusted models.
Conclusions
In children with asthma treated with inhaled corticosteroids, vitamin D deficiency is associated with poorer lung function than in children with vitamin D insufficiency or sufficiency.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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