Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis
Wark PA, Lau R, Norat T, Kampman E
The American journal of clinical nutrition · 50 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Imperial College London
- Universidad u hospital
- Radboud Universiteit
- Organización sin fines de lucro
- World Cancer Research Fund
- Universidad u hospital
- Wageningen University and Research
Según 4 financiadores declarados.
Publicación
- Publicado
- 2012-08-03 · Am J Clin Nutr · vol. 96 · número 3 · págs. 622–631
- Editorial
- Elsevier BV
- Citado
- 87 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, colorectal cancer, colorectal adenoma, advanced adenoma, cancer risk, calcium to magnesium ratio, body mass index, cancer prevention
- MeSH
- humans, adenoma, carcinoma, colorectal neoplasms, magnesium, neoplasm staging, body mass index, diet, risk, case-control studies, age factors, female, male, overweight
4 autores
- Petra A. Wark🇬🇧Imperial College London
- Rosa Lau🇬🇧🇳🇱Imperial College London; Wageningen University & Research
- Teresa Norat🇬🇧🇳🇱Imperial College London; Wageningen University & Research
- Ellen Kampman🇬🇧🇳🇱Imperial College London; Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation.
Objective
We evaluated the hypothesis of whether higher dietary magnesium intake is associated with reduced colorectal tumor risk.
Design
A case-control study on colorectal adenomas (768 cases; 709 polyp-free control subjects) and a meta-analysis of colorectal adenomas (3 case-control studies) and carcinomas (6 prospective cohort studies) were conducted. Dietary magnesium was estimated from food-frequency questionnaires in the case-control study and most studies in the meta-analyses. Data analysis comprised multiple logistic regression analysis (case-control study) and fixed- and random-effects meta-analyses.
Results
The case-control study showed a nonsignificant inverse association between dietary magnesium intake and risk of colorectal adenomas (OR for every 100-mg/d increase: 0.81; 95% CI: 0.62, 1.06). However, inverse associations were observed only in subjects with BMI (in kg/m²) ≥25, in subjects aged ≥55 y, and for advanced adenomas. Associations did not vary by the calcium-to-magnesium intake ratio. In the meta-analysis, every 100-mg/d increase in magnesium intake was associated with 13% lower risk of colorectal adenomas (OR: 0.87; 95% CI: 0.75, 1.00) and 12% lower risk of colorectal cancer (RR: 0.88; 95% CI: 0.81, 0.97).
Conclusions
Our findings support the hypothesis that higher intakes of dietary magnesium are associated with lower risk of colorectal tumors. The consumption of magnesium-rich foods may be a new avenue to explore further in the search for cancer-prevention strategies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.