Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial
Larsen T, Mose FH, Bech JN, Hansen AB, Pedersen EB
American journal of hypertension · 117 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Region Midtjylland
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-08-02 · Am J Hypertens · vol. 25 · número 11 · págs. 1215–1222
- Editorial
- Oxford University Press
- Citado
- 179 citas · más que el 99% de estudios similares · 13.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Blood Pressure and Hypertension Studies · Cardiovascular Health and Disease Prevention
- Palabras clave
- vitamin D3 supplementation, vitamin D deficiency, hypertension, blood pressure, 25-hydroxyvitamin D, winter, vitamin D insufficiency, central blood pressure, arterial stiffness, pulse wave velocity, ambulatory blood pressure
- MeSH
- humans, hypertension, vitamin d deficiency, cholecalciferol, double-blind method, seasons, blood pressure, aged, middle aged, denmark, female, male, vascular stiffness
5 autores
- T. Larsen🇩🇰 · autor de correspondenciaRegional Hospital Holstebro
- Frank Holden Mose🇩🇰Regional Hospital Holstebro
- Jesper Nørgaard Bech🇩🇰Regional Hospital Holstebro
- A. B. Hansen🇩🇰Regional Hospital Holstebro
- Erling Bjerregaard Pedersen🇩🇰Regional Hospital Holstebro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low 25-hydroxy-vitamin D (25(OH)D) levels are inversely related to blood pressure (BP) and have been associated with incident hypertension. In people living at northern latitudes diminished cholecalciferol synthesis in the winter increases the risk of vitamin D deficiency. We wanted to test the hypothesis that daily cholecalciferol supplementation in the winter lowers BP in patients with hypertension.
Methods
We investigated the effect of 75 µg (3,000 IU) cholecalciferol per day in a randomized, placebo-controlled, double-blind study in 130 hypertensive patients residing in Denmark (56º N). Ambulatory BP (24-h BP) and arterial stiffness were measured before and after 20 weeks of treatment, that took place between October and March.
Results
A total of 112 patients (mean age 61 ± 10) with a baseline p-25(OH)D of 23 ± 10 ng/ml completed the study. Compared with placebo, a nonsignificant 3/1 mm Hg (P = 0.26/0.18) reduction was found in 24-h BP. In patients with vitamin D insufficiency (<32 ng/ml) at baseline (n = 92), 24-h BP decreased by 4/3 mm Hg (P = 0.05/0.01). Central BP (CBP) estimated by applanation tonometry and calibrated with a standardized office BP was reduced by 7/2 mm Hg (P = 0.007/0.15) vs. placebo. No differences in carotid-femoral pulse wave velocity (PWV) or central augmentation index (AIx) were found between treatment arms.
Conclusions
Cholecalciferol supplementation, by a dose that effectively increased vitamin D levels, did not reduce 24-h BP, although central systolic BP decreased significantly. In a post-hoc subgroup analysis of 92 subjects with baseline p-25(OH)D levels <32 ng/ml, significant decreases in 24-h systolic and diastolic BP occurred during cholecalciferol supplementation.
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