Financiado en parte por California Walnut Commission
A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk
Fernández-Real JM, Bulló M, Moreno-Navarrete JM, Ricart W, Ros E, Estruch R, Salas-Salvadó J
The Journal of clinical endocrinology and metabolism · 76 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- California Walnut Commission
- Universidad u hospital
- Universitat Rovira i Virgili
- Gobierno
- Instituto de Salud Carlos III
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-10-01 · J Clin Endocrinol Metab · vol. 97 · número 10 · págs. 3792–3798
- Editorial
- Oxford University Press
- Citado
- 91 citas · más que el 97% de estudios similares · 8.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Vitamin K Research Studies · Bone health and osteoporosis research
- Palabras clave
- Osteocalcin, Mediterranean diet, Endocrinology, Internal medicine, Medicine, Osteoporosis, Resorption, Body mass index, Biology, Alkaline phosphatase, Biochemistry
- MeSH
- humans, nuts, osteoporosis, cardiovascular diseases, collagen type i, plant oils, peptides, osteocalcin, treatment outcome, diet, fat-restricted, risk factors, longitudinal studies, diet, mediterranean, aging, homeostasis, aged, aged, 80 and over, middle aged, male, biomarkers, olive oil
7 autores
- José Manuel Fernández‐Real🇪🇸 · autor de correspondenciaInstitut d'Investigació Biomèdica de Girona; Hospital Universitari de Girona Doctor Josep Trueta
- Mònica Bulló🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- José María Moreno‐Navarrete🇪🇸Hospital Universitari de Girona Doctor Josep Trueta
- Wifredo Ricart🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitari de Girona Doctor Josep Trueta
- Emilio Peña Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínic de Barcelona
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans.
Objective
The objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk.
Design
Longitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions.
Results
Baseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort.
Conclusions
Consumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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