Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis
Widmer RJ, Freund MA, Flammer AJ, Sexton J, Lennon R, Romani A, Mulinacci N, Vinceri FF, Lerman LO, Lerman A
European journal of nutrition · 77 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Mayo Clinic
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- Swiss National Science Foundation
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (132551); National Heart, Lung, and Blood Institute (R01 HL 092954); National Heart, Lung, and Blood Institute (P01HL085307); National Heart, Lung, and Blood Institute (HL085307)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2012-08-07 · Eur J Nutr · vol. 52 · número 3 · págs. 1223–1231
- Editorial
- Springer Science+Business Media
- Citado
- 123 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Edible Oils Quality and Analysis · Cardiovascular Health and Disease Prevention · Phytochemicals and Antioxidant Activities
- Palabras clave
- olive oil, polyphenols, epigallocatechin gallate, early atherosclerosis, endothelial dysfunction, endothelial function, inflammation, oxidative stress, white blood cell count, monocytes, platelets, soluble intercellular adhesion molecule, cardiovascular disease prevention
- MeSH
- endothelium, vascular, humans, camellia sinensis, plant leaves, plant oils, anti-inflammatory agents, non-steroidal, antioxidants, severity of illness index, double-blind method, oxidative stress, diet, mediterranean, food, fortified, adult, middle aged, patient dropouts, minnesota, female, male, atherosclerosis, polyphenols, olive oil
10 autores
- Robert Jay Widmer🇺🇸Mayo Clinic
- M. A. Freund🇺🇸Mayo Clinic
- Andreas J. Flammer🇺🇸Mayo Clinic
- J. M. Sexton🇺🇸Mayo Clinic
- Ryan J. Lennon🇺🇸Mayo Clinic
- Annalisa Romani🇮🇹University of Florence
- Nádia Mulinacci🇮🇹University of Florence
- F. F. Vinceri🇮🇹University of Florence
- Amir Lerman🇺🇸Mayo Clinic
- Amir Lerman🇺🇸 · autor de correspondenciaMayo Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Diets rich in plant-derived polyphenols such as olive oil (OO) and/or catechins such as epigallocatechin 3-gallate (EGCG) have been shown to reduce the incidence of cardiovascular diseases, potentially by improving endothelial function, an important surrogate for atherosclerosis. The possible augmentation of endothelial function with the combined efforts of OO and EGCG is intriguing, yet unknown.
Methods
Eighty-two patients with early atherosclerosis (presence of endothelial dysfunction) were enrolled in this double-blind, randomized trial with 52 completing the study. The aim of the study was to compare the effect of a daily intake of 30 ml simple OO, with 30 ml of EGCG-supplemented OO, on endothelial function as well as on inflammation and oxidative stress after a period of 4 months. Endothelial function was assessed noninvasively via peripheral arterial tonometry (Endo-PAT®).
Results
After 4 months, when OO and EGCG-supplemented OO groups were combined, OO significantly improved endothelial function (RHI, 1.59 ± 0.25-1.75 ± 0.45; p < 0.05). However, there were no significant differences in results between the two olive oil groups. Interestingly, with OO supplementation there was a significant reduction in inflammatory parameters: sICAM (196 to 183 ng/mL, p = < 0.001); white blood cells (WBCs) (6.0 × 10⁹/L-5.8 × 10⁹/L, p < 0.05); monocytes (0.48 × 10⁹/L to 0.44 × 10⁹/L, p = 0.05); lymphocytes (1.85 × 10⁹/L to 1.6 × 10⁹/L, p = 0.01); and platelets (242-229 × 10⁹/L, p = 0.047).
Conclusions
Improvement in endothelial dysfunction in patients with early atherosclerosis in association with significant reduction in leukocytes may suggest an important role of early cellular inflammatory mediators on endothelial function. The current study supports one potential mechanism for the role of olive oil, independent of EGCG, modestly supplemented to a healthy cardiovascular diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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