Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients - a triple blinded randomized controlled trial
Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 78 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-08-10 · Radiother Oncol · vol. 104 · número 3 · págs. 349–354
- Editorial
- Elsevier BV
- Citado
- 120 citas · más que el 97% de estudios similares · 6.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, concurrent chemoradiotherapy, head and neck cancer, cisplatin, radiation toxicity, oral pain, dysphagia, opioid analgesic use, He-Ne laser, mucositis prevention
- MeSH
- humans, head and neck neoplasms, stomatitis, pain measurement, prospective studies, adult, aged, middle aged, female, male, chemoradiotherapy, low-level light therapy
5 autores
- Ajay Prashad Gautam🇮🇳Manipal Academy of Higher Education
- Donald Fernandes🇮🇳Manipal Academy of Higher Education
- Mamidipudi Srinivasa Vidyasagar🇮🇳 · autor de correspondenciaFather Muller Medical College Hospital
- Arun Gundmi Maiya🇮🇳Manipal Academy of Higher Education
- Bejadi Manjunath Vadhiraja🇮🇳Manipal Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and purpose
Oral mucositis (OM) is most cumbersome acute side effect of concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment. Several modalities have been tried to prevent and treat OM, but none proved completely successful until date. We used prophylactic low level laser therapy (LLLT) for the prevention and treatment of CCRT induced OM.
Materials and methods
In this triple blinded study, 221 HNC patients scheduled to undergo CCRT (Cisplatin (1, 22, 43 day)+RT=66 Grays (2 Gy/fraction), 33 fractions, 5 fractions/week, for 45 days) were block randomized into laser (n=111) and placebo (n=110) group. Laser group received LLLT (HeNe, λ=632.8 nm, power-density=24 mW, dosage=3.0 J/point, total dosage/session=36-40 J, spot-size=1cm(2), 5 sessions/week) while placebo received sham treatment daily prior to radiation. OM (RTOG/EORTC Scale), oral pain (VAS), dysphagia (FIS), weight loss and CCRT break were assessed. Data were analyzed using frequencies and percentage, generalized estimating equations (GEE) and odds ratio.
Results
There was significant reduction in incidence of severe OM (F=16.64, df=8876, p<0.0001) and its associated pain (F=25.06, df=8876, p<0.0001), dysphagia (F=20.17, df=8876, p<0.0001) and opioid analgesics use (p<0.0001) in laser than placebo group patients.
Conclusions
LLLT decreased the incidence of CCRT induced severe OM and its associated pain, dysphagia and opioid analgesics use.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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