Financiado en parte por Mead Johnson Nutrition
Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia
Camargo CA, Ganmaa D, Frazier AL, Kirchberg FF, Stuart JJ, Kleinman K, Sumberzul N, Rich-Edwards JW
Pediatrics · 194 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Mead Johnson Nutrition
- Universidad u hospital
- Mongolian National University of Medical Sciences
Según 2 financiadores declarados.
Publicación
- Publicado
- 2012-08-20 · Pediatrics · vol. 130 · número 3 · págs. e561–e567
- Editorial
- American Academy of Pediatrics
- Citado
- 285 citas · más que el 100% de estudios similares · 24.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Pediatric health and respiratory diseases · Respiratory viral infections research
- Palabras clave
- vitamin D supplementation, acute respiratory infections, vitamin D deficiency, 25-hydroxyvitamin D, elementary school students, milk fortification, winter, Mongolia, wheezing
- MeSH
- milk, animals, humans, respiratory tract infections, vitamin d deficiency, acute disease, vitamin d, double-blind method, dietary supplements, food, fortified, child, mongolia
8 autores
- Carlos A. Camargo🇺🇸Harvard University; Massachusetts General Hospital
- Davaasambuu Ganmaa🇺🇸Harvard University
- A. Lindsay Frazier🇺🇸Harvard University; Dana-Farber Cancer Institute
- Franca Fabiana Kirchberg🇺🇸Massachusetts General Hospital
- Jennifer J. Stuart🇺🇸Brigham and Women's Hospital; Harvard University
- KEN P. KLEINMAN🇺🇸Harvard University; Harvard Pilgrim Health Care
- Nyamjav Sumberzul
- Janet Wilson Rich-Edwards🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Observational studies suggest that serum levels of 25-hydroxyvitamin D (25[OH]D) are inversely associated with acute respiratory infections (ARIs). We hypothesized that vitamin D supplementation of children with vitamin D deficiency would lower the risk of ARIs.
Methods
By using cluster randomization, classrooms of 744 Mongolian schoolchildren were randomly assigned to different treatments in winter (January-March). This analysis focused on a subset of 247 children who were assigned to daily ingestion of unfortified regular milk (control; n = 104) or milk fortified with 300 IU of vitamin D(3) (n = 143). This comparison was double-blinded. The primary outcome was the number of parent-reported ARIs over the past 3 months.
Results
At baseline, the median serum 25(OH)D level was 7 ng/mL (interquartile range: 5-10 ng/mL). At the end of the trial, follow-up was 99% (n = 244), and the median 25(OH)D levels of children in the control versus vitamin D groups was significantly different (7 vs 19 ng/mL; P < .001). Compared with controls, children receiving vitamin D reported significantly fewer ARIs during the study period (mean: 0.80 vs 0.45; P = .047), with a rate ratio of 0.52 (95% confidence interval: 0.31-0.89). Adjusting for age, gender, and history of wheezing, vitamin D continued to halve the risk of ARI (rate ratio: 0.50 [95% confidence interval: 0.28-0.88]). Similar results were found among children either below or above the median 25(OH)D level at baseline (rate ratio: 0.41 vs 0.57; P(interaction) = .27).
Conclusions
Vitamin D supplementation significantly reduced the risk of ARIs in winter among Mongolian children with vitamin D deficiency.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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