Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects
Beilfuss J, Berg V, Sneve M, Jorde R, Kamycheva E
Cytokine · 96 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-08-24 · Cytokine · vol. 60 · número 3 · págs. 870–874
- Editorial
- Elsevier BV
- Citado
- 133 citas · más que el 97% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Antioxidant Activity and Oxidative Stress
- Palabras clave
- vitamin D3, vitamin D supplementation, vitamin D status, interleukin-6, TNF-α, insulin resistance, C-reactive protein, obesity, overweight, metabolic syndrome, inflammation, HOMA-IR, QUICKI
- MeSH
- humans, insulin resistance, obesity, cholecalciferol, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, dietary supplements, adult, aged, middle aged, female, male, overweight, young adult, biomarkers
5 autores
- Julia Beilfuss🇳🇴 · autor de correspondenciaUniversity Hospital of North Norway
- Vivian Berg🇳🇴University Hospital of North Norway
- Monica Sneve🇳🇴Oslo University Hospital
- Rolf Jorde🇳🇴UiT The Arctic University of Norway
- Elena Kamycheva🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Insufficient vitamin D status has been linked to autoimmune diseases, cancer and metabolic disorders, like obesity and insulin resistance. In vitro and animal studies suggest that vitamin D may play a crucial role in immune activation and inflammation. The relation between vitamin D and pro-inflammatory cytokines is not completely established. Furthermore, it is not known if the effect of vitamin D on entities of metabolic syndrome is mediated through its effect on cytokines or other biomarkers. The objectives of this study were to investigate if there is a relationship between vitamin D status and such pro-inflammatory cytokines as tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hs-CRP) in patients with overweigh and obesity. We also proposed that the intervention with high dose of cholecalciferol may have effect on the cytokine levels and result in corresponding changes in the measures of insulin resistance (HOMA-IR and QUICKI). Serum levels of IL-6, TNF-α and hs-CRP were measured in 332 overweight and obese subjects who completed a 1-year randomised intervention with either 40,000 IU vitamin D (cholecalciferol) per week or 20,000 IU vitamin D per week, or placebo. We found significant associations between IL-6, TNF-α, vitamin D and insulin resistance indices at baseline. One year intervention with vitamin D decreased serum IL-6 levels; however hs-CRP levels were significantly increased. Neither measures of insulin resistance, nor TNF-α were influenced by a 1-year vitamin D supplementation.
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