Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
Lee LK, Shahar S, Chin AV, Yusoff NA
Psychopharmacology · 156 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-08-29 · Psychopharmacology (Berl) · vol. 225 · número 3 · págs. 605–612
- Editorial
- Springer Science+Business Media
- Citado
- 219 citas · más que el 99% de estudios similares · 11.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- docosahexaenoic acid, fish oil supplementation, mild cognitive impairment, memory, working memory, verbal memory, executive function, attention, psychomotor speed, visual construction, older adults, low socioeconomic status, tolerability, Alzheimer's disease prevention
- MeSH
- humans, docosahexaenoic acids, fish oils, treatment outcome, severity of illness index, analysis of variance, double-blind method, cognition, memory, short-term, psychomotor performance, cognition disorders, socioeconomic factors, dietary supplements, aged, middle aged, female, male
4 autores
- Lai Kuan Lee🇲🇾National University of Malaysia
- Suzana Shahar🇲🇾 · autor de correspondenciaNational University of Malaysia
- Ai‐Vyrn Chin🇲🇾University of Malaya
- Noor Aini Mohd Yusoff
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer's disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI).
Objectives
This study investigated the effects of fish oil supplementation on cognitive function in elderly person with MCI.
Methods
This was a 12-month, randomised, double-blind, placebo-controlled study using fish oil supplementation with concentrated docosahexaenoic acid (DHA). Thirty six low-socioeconomic-status elderly subjects with MCI were randomly assigned to receive either concentrated DHA fish oil (n = 18) or placebo (n = 18) capsules. The changes of memory, psychomotor speed, executive function and attention, and visual-constructive skills were assessed using cognitive tests. Secondary outcomes were safety and tolerability of the DHA concentrate.
Results
The fish oil group showed significant improvement in short-term and working memory (F = 9.890; ηp (2) = 0.254; p < 0.0001), immediate verbal memory (F = 3.715; ηp (2) = 0.114; p < 0.05) and delayed recall capability (F = 3.986; ηp (2) = 0.121; p < 0.05). The 12-month change in memory (p < 0.01) was significantly better in the fish oil group. Fish oil consumption was well tolerated, and the side effects were minimal and self-limiting.
Conclusions
This study suggested the potential role of fish oil to improve memory function in MCI subjects. Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.
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