Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial
D'Vaz N, Meldrum SJ, Dunstan JA, Martino D, McCarthy S, Metcalfe J, Tulic MK, Mori TA, Prescott SL
Pediatrics · 99 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-09-03 · Pediatrics · vol. 130 · número 4 · págs. 674–682
- Editorial
- American Academy of Pediatrics
- Citado
- 135 citas · más que el 99% de estudios similares · 13.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases
- Palabras clave
- fish oil supplementation, omega-3 polyunsaturated fatty acids, docosahexaenoic acid, eicosapentaenoic acid, infant allergy prevention, atopic dermatitis, food allergy, asthma, allergen sensitization, recurrent wheezing, arachidonic acid, breast milk fatty acids, olive oil placebo
- MeSH
- milk, human, humans, hypersensitivity, immediate, docosahexaenoic acids, eicosapentaenoic acid, fish oils, skin tests, treatment outcome, drug administration schedule, logistic models, risk, follow-up studies, dietary supplements, infant, infant, newborn, female, male, intention to treat analysis, biomarkers
9 autores
- Nina D’Vaz
- Suzanne Jacqueline Meldrum
- Janet A. Dunstan
- David Martino
- S. McCarthy
- Jessica R. Metcalfe
- Meri K. Tulić
- Trevor Anthony Mori🇦🇺The University of Western Australia; Royal Perth Hospital
- Susan L. Prescott
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Relative deficiency of dietary omega 3 polyunsaturated fatty acids (n-3 PUFA) has been implicated in the rising allergy prevalence in Westernized countries. Fish oil supplementation may provide an intervention strategy for primary allergy prevention. The objective of this study was to assess the effect of fish oil n-3 PUFA supplementation from birth to 6 months of age on infant allergic disease.
Methods
In a double-blind randomized controlled trial, 420 infants at high atopic risk received a daily supplement of fish oil containing 280 mg docosahexaenoic acid and 110 mg eicosapentaenoic acid or a control (olive oil), from birth to age 6 months. PUFA levels were measured in 6-month-old infants' erythrocytes and plasma and their mothers' breast milk. Eczema, food allergy, asthma and sensitization were assessed in 323 infants for whom clinical follow-up was completed at 12 months of age.
Results
At 6 months of age, infant docosahexaenoic acid and eicosapentaenoic acid levels were significantly higher (both P < .05) and erythrocyte arachidonic acid levels were lower (P = .003) in the fish oil group. Although n-3 PUFA levels at 6 months were associated with lower risk of eczema (P = .033) and recurrent wheeze (P = .027), the association with eczema was not significant after multiple comparisons and there was no effect of the intervention per se on the primary study outcomes. Specifically, between-group comparisons revealed no differences in the occurrence of allergic outcomes including sensitization, eczema, asthma, or food allergy.
Conclusions
Postnatal fish oil supplementation improved infant n-3 status but did not prevent childhood allergic disease.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.