Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans
Ramsden CE, Ringel A, Feldstein AE, Taha AY, MacIntosh BA, Hibbeln JR, Majchrzak-Hong SF, Faurot KR, Rapoport SI, Cheon Y, Chung YM, Berk M, Mann JD
Prostaglandins, leukotrienes, and essential fatty acids · 152 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
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- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- MAYDAY Fund
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Nutrition Obesity Research Center, University of North Carolina
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Complementary and Alternative Medicine
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCCIH NIH HHS
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z99‐AA999999); National Center for Complementary and Integrative Health (T-32 AT003378); National Center for Complementary and Alternative Medicine (AT003378); National Center for Research Resources (UL1RR025747); National Institute of Diabetes and Digestive and Kidney Diseases (DK-056350); Nutrition Obesity Research Center, University of North Carolina (DK056350); National Institutes of Health (DK-056350); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2012-09-05 · Prostaglandins Leukot Essent Fatty Acids · vol. 87 · número 4-5 · págs. 135–141
- Editorial
- Elsevier BV
- Citado
- 192 citas · más que el 98% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- linoleic acid, chronic headache, dietary intervention, biomarkers, Alzheimer's dementia, nonalcoholic steatohepatitis, cardiovascular disease, chronic pain
- MeSH
- humans, headache, dietary fats, linoleic acids, linoleic acid, linoleic acids, conjugated, spectrometry, mass, electrospray ionization, adult, middle aged, female, male, tandem mass spectrometry, young adult
13 autores
- Christopher E. Ramsden🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Amit Ringel🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Ariel E. Feldstein🇺🇸Cleveland Clinic; University of California San Diego
- Ameer Y. Taha🇺🇸National Institutes of Health; National Institute on Aging
- Beth MacIntosh🇺🇸University of North Carolina at Chapel Hill
- Joseph R. Hibbeln🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Sharon F. Majchrzak‐Hong🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- Keturah R. Faurot🇺🇸University of North Carolina at Chapel Hill
- Stanley Isaac Rapoport🇺🇸National Institutes of Health; National Institute on Aging
- Yewon Cheon🇺🇸National Institutes of Health; National Institute on Aging
- Yoon-Mi Chung🇺🇸Cleveland Clinic
- Michael Berk🇺🇸Cleveland Clinic
- J. Douglas Mann🇺🇸University of North Carolina at Chapel Hill
Resumen
El texto original del estudio, en el idioma en que se publicó.
Linoleic acid (LA) is the most abundant polyunsaturated fatty acid in human diets, a major component of human tissues, and the direct precursor to the bioactive oxidized LA metabolites (OXLAMs), 9- and 13 hydroxy-octadecadienoic acid (9- and 13-HODE) and 9- and 13-oxo-octadecadienoic acid (9- and 13-oxoODE). These four OXLAMs have been mechanistically linked to pathological conditions ranging from cardiovascular disease to chronic pain. Plasma OXLAMs, which are elevated in Alzheimer's dementia and non-alcoholic steatohepatitis, have been proposed as biomarkers useful for indicating the presence and severity of both conditions. Because mammals lack the enzymatic machinery needed for de novo LA synthesis, the abundance of LA and OXLAMs in mammalian tissues may be modifiable via diet. To examine this issue in humans, we measured circulating LA and OXLAMs before and after a 12-week LA lowering dietary intervention in chronic headache patients. Lowering dietary LA significantly reduced the abundance of plasma OXLAMs, and reduced the LA content of multiple circulating lipid fractions that may serve as precursor pools for endogenous OXLAM synthesis. These results show that lowering dietary LA can reduce the synthesis and/or accumulation of oxidized LA derivatives that have been implicated in a variety of pathological conditions. Future studies evaluating the clinical implications of diet-induced OXLAM reductions are warranted.
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