Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis
Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS
JAMA · 663 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-09-11 · JAMA · vol. 308 · número 10 · pág. 1024
- Editorial
- American Medical Association
- Citado
- 963 citas · más que el 100% de estudios similares · 118.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Cardiac Health and Mental Health
- Palabras clave
- omega-3 fatty acids, polyunsaturated fatty acids, dietary supplementation, cardiovascular disease, myocardial infarction, stroke, sudden cardiac death, cardiovascular mortality, all-cause mortality, implantable cardioverter-defibrillator, cardiovascular risk reduction, randomized controlled trials meta-analysis, subgroup analysis, meta-regression, heterogeneity, risk mitigation
- MeSH
- humans, cardiovascular diseases, death, sudden, cardiac, myocardial infarction, fatty acids, omega-3, cause of death, risk, dietary supplements, aged, middle aged, randomized controlled trials as topic, stroke
5 autores
- Evangelos C. Rizos🇬🇷University of Ioannina; University Hospital of Ioannina
- Evangelia Ntzani
- Eftychia Bika
- Michael S. Kostapanos
- Moses Elisaf
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Considerable controversy exists regarding the association of omega-3 polyunsaturated fatty acids (PUFAs) and major cardiovascular end points.
Objective
To assess the role of omega-3 supplementation on major cardiovascular outcomes.
Data sources
MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through August 2012.
Study selection
Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac death, sudden death, myocardial infarction, and stroke.
Data extraction
Descriptive and quantitative information was extracted; absolute and relative risk (RR) estimates were synthesized under a random-effects model. Heterogeneity was assessed using the Q statistic and I2. Subgroup analyses were performed for the presence of blinding, the prevention settings, and patients with implantable cardioverter-defibrillators, and meta-regression analyses were performed for the omega-3 dose. A statistical significance threshold of .0063 was assumed after adjustment for multiple comparisons.
Data synthesis
Of the 3635 citations retrieved, 20 studies of 68,680 patients were included, reporting 7044 deaths, 3993 cardiac deaths, 1150 sudden deaths, 1837 myocardial infarctions, and 1490 strokes. No statistically significant association was observed with all-cause mortality (RR, 0.96; 95% CI, 0.91 to 1.02; risk reduction [RD] -0.004, 95% CI, -0.01 to 0.02), cardiac death (RR, 0.91; 95% CI, 0.85 to 0.98; RD, -0.01; 95% CI, -0.02 to 0.00), sudden death (RR, 0.87; 95% CI, 0.75 to 1.01; RD, -0.003; 95% CI, -0.012 to 0.006), myocardial infarction (RR, 0.89; 95% CI, 0.76 to 1.04; RD, -0.002; 95% CI, -0.007 to 0.002), and stroke (RR, 1.05; 95% CI, 0.93 to 1.18; RD, 0.001; 95% CI, -0.002 to 0.004) when all supplement studies were considered.
Conclusion
Overall, omega-3 PUFA supplementation was not associated with a lower risk of all-cause mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute measures of association.
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