A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women
Salehpour A, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M
Nutrition journal · 128 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
- Universidad u hospital
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2012-09-22 · Nutr J · vol. 11 · número 1 · pág. 78
- Editorial
- BioMed Central
- Citado
- 192 citas · más que el 98% de estudios similares · 7.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Bone health and osteoporosis research
- Palabras clave
- vitamin D3 supplementation, vitamin D3, fat mass, obesity, overweight women, 25-hydroxyvitamin D, parathyroid hormone, body composition, waist circumference, vitamin D deficiency
- MeSH
- humans, vitamin d deficiency, obesity, cholecalciferol, calcifediol, 25-hydroxyvitamin d 2, parathyroid hormone, body mass index, double-blind method, patient compliance, time factors, dietary supplements, adult, middle aged, patient dropouts, iran, female, adiposity, overweight
8 autores
- Amin Salehpour🇮🇷Tehran University of Medical Sciences
- Farhad Hosseinpanah🇮🇷 · autor de correspondenciaResearch Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Farzad Shidfar🇮🇷Tehran University of Medical Sciences
- Mohammadreza Vafa🇮🇷Tehran University of Medical Sciences
- Maryam Razaghi🇮🇷Tehran University of Medical Sciences
- Sahar Dehghani🇮🇷Tehran University of Medical Sciences
- A Houshyarrad🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Mahmood Reza Gohari🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D concentrations are linked to body composition indices, particularly body fat mass. Relationships between hypovitaminosis D and obesity, described by both BMI and waist circumference, have been mentioned. We have investigated the effect of a 12-week vitamin D3 supplementation on anthropometric indices in healthy overweight and obese women.
Methods
In a double-blind, randomized, placebo-controlled, parallel-group trial, seventy-seven participants (age 38 ± 8.1 years, BMI 29.8 ± 4.1 kg/m²) were randomly allocated into two groups: vitamin D (25 μg per day as cholecalciferol) and placebo (25 μg per day as lactose) for 12 weeks. Body weight, height, waist, hip, fat mass, 25(OH) D, iPTH, and dietary intakes were measured before and after the intervention.
Results
Serum 25(OH)D significantly increased in the vitamin D group compared to the placebo group (38.2 ± 32.7 nmol/L vs. 4.6 ± 14.8 nmol/L; P<0.001) and serum iPTH concentrations were decreased by vitamin D3 supplementation (-0.26 ± 0.57 pmol/L vs. 0.27 ± 0.56 pmol/L; P<0.001). Supplementation with vitamin D3 caused a statistically significant decrease in body fat mass in the vitamin D group compared to the placebo group (-2.7 ± 2.1 kg vs. -0.47 ± 2.1 kg; P<0.001). However, body weight and waist circumference did not change significantly in both groups. A significant reverse correlation between changes in serum 25(OH) D concentrations and body fat mass was observed (r = -0.319, P = 0.005).
Conclusion
Among healthy overweight and obese women, increasing 25(OH) D concentrations by vitamin D3 supplementation led to body fat mass reduction.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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