Vitamin D, cognition, and dementia: a systematic review and meta-analysis
Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P
Neurology · 317 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-09-24 · Neurology · vol. 79 · número 13 · págs. 1397–1405
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 429 citas · más que el 100% de estudios similares · 24.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Dementia and Cognitive Impairment Research · Neurological Disease Mechanisms and Treatments
- Palabras clave
- vitamin D, cognitive function, dementia, Alzheimer's disease, Mini-Mental State Examination, vitamin D deficiency, cognitive impairment, vitamin D supplementation
- MeSH
- humans, dementia, vitamin d, cognition, cognition disorders, randomized controlled trials as topic
8 autores
- Cynthia M. Balion🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- Lauren E. Griffith🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- Lisa Strifler🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- Matthew Henderson🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- Christopher Patterson🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- George A. Heckman🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- David J. Llewellyn🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
- Parminder Raina🇨🇦🇬🇧University of Waterloo; University of Exeter; Research Institute for Aging; Peninsula College of Medicine and Dentistry; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the association between cognitive function and dementia with vitamin D concentration in adults.
Methods
Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I² methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g.
Results
Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D <50 nmol/L to those with values ≥50 nmol/L. There was significant heterogeneity among the studies that compared the WMD for MMSE but an overall positive effect for the higher vitamin D group (1.2, 95% confidence interval [CI] 0.5 to 1.9; I² = 0.65; p = 0.002). The small positive effect persisted despite several sensitivity analyses. Six studies presented data comparing Alzheimer disease (AD) to controls but 2 utilized a method withdrawn from commercial use. For the remaining 4 studies the AD group had a lower vitamin D concentration compared to the control group (WMD = -6.2 nmol/L, 95% CI -10.6 to -1.8) with no heterogeneity (I² < 0.01; p = 0.53).
Conclusion
These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD. Further studies are required to determine the significance and potential public health benefit of this association.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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