Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial
Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E
Brain, behavior, and immunity · 182 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Ohio State University
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NIH Clinical Center
- Gobierno
- NIA NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIH
- Subvenciones
- National Institute on Aging (R01 AG038621); National Institute on Aging (AG038621); National Center for Research Resources (UL1RR025755); National Cancer Institute (CA16058); National Institute on Aging (R01AG029562); National Cancer Institute (P30CA016058); National Institute on Aging (AG029562)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2012-09-23 · Brain Behav Immun · vol. 28 · págs. 16–24
- Editorial
- Elsevier BV
- Citado
- 259 citas · más que el 99% de estudios similares · 15.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, leukocyte telomere length, telomerase, oxidative stress, F2-isoprostanes, n-6/n-3 ratio, inflammatory cytokines, cellular aging, dietary supplementation
- MeSH
- leukocytes, humans, telomerase, fatty acids, omega-3, double-blind method, depression, oxidative stress, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male, telomere shortening, cellular senescence
9 autores
- Janice K. Kiecolt‐Glaser🇺🇸 · autor de correspondenciaThe Ohio State University
- Elissa S. Epel🇺🇸University of California, San Francisco
- Martha Ann Belury🇺🇸The Ohio State University
- Rebecca Andridge🇺🇸The Ohio State University
- Jue Lin🇺🇸University of California, San Francisco
- Ronald Glaser🇺🇸The Ohio State University
- William B. Malarkey🇺🇸The Ohio State University
- Beom Seuk Hwang🇺🇸The Ohio State University
- Elizabeth Helen Blackburn🇺🇸University of California, San Francisco
Resumen
El texto original del estudio, en el idioma en que se publicó.
Shorter telomeres have been associated with poor health behaviors, age-related diseases, and early mortality. Telomere length is regulated by the enzyme telomerase, and is linked to exposure to proinflammatory cytokines and oxidative stress. In our recent randomized controlled trial, omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation lowered the concentration of serum proinflammatory cytokines. This study assessed whether n-3 PUFA supplementation also affected leukocyte telomere length, telomerase, and oxidative stress. In addition to testing for group differences, changes in the continuous n-6:n-3 PUFA ratio were assessed to account for individual differences in adherence, absorption, and metabolism. The double-blind four-month trial included 106 healthy sedentary overweight middle-aged and older adults who received (1) 2.5g/day n-3 PUFAs, (2) l.25g/day n-3 PUFAs, or (3) placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Supplementation significantly lowered oxidative stress as measured by F2-isoprostanes (p=0.02). The estimated geometric mean log-F2-isoprostanes values were 15% lower in the two supplemented groups compared to placebo. Although group differences for telomerase and telomere length were nonsignificant, changes in the n-6:n-3 PUFA plasma ratios helped clarify the intervention's impact: telomere length increased with decreasing n-6:n-3 ratios, p=0.02. The data suggest that lower n-6:n-3 PUFA ratios can impact cell aging. The triad of inflammation, oxidative stress, and immune cell aging represents important pre-disease mechanisms that may be ameliorated through nutritional interventions. This translational research broadens our understanding of the potential impact of the n-6:n-3 PUFA balance. ClinicalTrials.gov identifier: NCT00385723.
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