Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome
Blesso CN, Andersen CJ, Barona J, Volek JS, Fernandez ML
Metabolism: clinical and experimental · 109 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-09-26 · Metabolism · vol. 62 · número 3 · págs. 400–410
- Editorial
- Elsevier BV
- Citado
- 142 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- metabolic syndrome, carbohydrate restriction, lipoprotein profile, insulin resistance, atherogenic dyslipidemia, HDL cholesterol, LDL particle size, oxidized LDL, LCAT activity, cholesteryl ester transfer protein, apolipoproteins, triglycerides, dietary cholesterol
- MeSH
- humans, insulin resistance, phosphatidylcholine-sterol o-acyltransferase, triglycerides, lipoproteins, ldl, apolipoproteins, ultrasonography, single-blind method, particle size, eggs, middle aged, female, male, diet, carbohydrate-restricted, cholesterol ester transfer proteins, metabolic syndrome
5 autores
- Christopher N. Blesso🇺🇸University of Connecticut
- Catherine J. Andersen🇺🇸University of Connecticut
- Jacqueline Barona🇺🇸🇨🇴University of Connecticut; Universidad de Antioquia
- Jeff S. Volek🇺🇸University of Connecticut
- María Luz Fernández🇺🇸 · autor de correspondenciaUniversity of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We investigated if daily egg feeding, along with carbohydrate restriction, would alter lipoprotein metabolism and influence atherogenic lipoprotein profiles and insulin resistance in men and women with metabolic syndrome (MetS).
Methods
In a randomized, single-blind, parallel design, participants consumed either 3 whole eggs/day (EGG, n=20) or the equivalent amount of yolk-free egg substitute (SUB, n=17), as part of a moderately carbohydrate-restricted diet (25%-30% energy) for 12 weeks. Plasma lipids, apolipoproteins (apos), oxidized LDL (oxLDL), cholesteryl ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) activities were assessed at baseline and week 12. Lipoprotein particle concentrations and sizes were measured by nuclear magnetic resonance spectroscopy.
Results
Atherogenic dyslipidemia improved for all individuals as evidenced by reductions in plasma triglycerides, apoC-III, apoE, oxLDL, VLDL particle diameter, large VDL, total IDL, small LDL, and medium LDL particles (P<0.05). Furthermore, there were increases in HDL-cholesterol, large LDL and large HDL particles (P<0.05) for all individuals. However, there were greater increases in HDL-cholesterol and large HDL particles, and reductions in total VLDL and medium VLDL particles for those consuming EGG compared to SUB (P<0.05). Plasma insulin and insulin resistance (HOMA-IR) were reduced, while LCAT activity, and both HDL and LDL diameters increased over time in the EGG group only (P<0.05).
Conclusions
Incorporating daily whole egg intake into a moderately carbohydrate-restricted diet provides further improvements in the atherogenic lipoprotein profile and in insulin resistance in individuals with MetS.
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