High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D
Davidson MB, Duran P, Lee ML, Friedman TC
Diabetes care · 155 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Center for Research Resources
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIDA NIH HHS
- Gobierno
- NIMHD NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (S06 GM068510); National Institute on Drug Abuse (R24DA-017298); National Center for Research Resources (U54-RR026138); National Institute on Minority Health and Health Disparities (U54MD007598)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2012-10-02 · Diabetes Care · vol. 36 · número 2 · págs. 260–266
- Editorial
- American Diabetes Association
- Citado
- 207 citas · más que el 100% de estudios similares · 15.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Management and Research · Diabetes Treatment and Management
- Palabras clave
- vitamin D supplementation, prediabetes, vitamin D deficiency, 25-hydroxyvitamin D, insulin secretion, insulin sensitivity, type 2 diabetes prevention, glycemic control, HbA1c, oral glucose tolerance test
- MeSH
- humans, prediabetic state, vitamin d, glucose tolerance test, double-blind method, dietary supplements, middle aged, female, male, glycated hemoglobin
4 autores
- Mayer B. Davidson🇺🇸Charles R. Drew University of Medicine and Science
- Petra A. Duran🇺🇸 · autor de correspondenciaCharles R. Drew University of Medicine and Science
- Martin L. Lee🇺🇸Charles R. Drew University of Medicine and Science
- Theodore C. Friedman🇺🇸Charles R. Drew University of Medicine and Science
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Low vitamin D levels predict the development of diabetes. This double-blind, randomized, control study in subjects with prediabetes and hypovitaminosis D evaluated whether high doses of vitamin D for 1 year affected insulin secretion, insulin sensitivity, and the development of diabetes.
Research design and methods
A total of 1,551 subjects ≥40 years of age not known to have diabetes were screened with A1C levels. Subjects with A1C levels of 5.8-6.9% underwent an oral glucose tolerance test (OGTT). Subjects with prediabetes and 25-OH vitamin D (25-OHD) levels <30 ng/mL were randomized to receive weekly placebo (n = 53) or vitamin D (n = 56) with doses based on body weight and baseline 25-OHD levels. OGTTs were performed 3, 6, 9, and 12 months later. Insulin secretion and sensitivity were measured, and the proportion of subjects developing diabetes was assessed.
Results
25-OHD levels rapidly rose from 22 to nearly 70 ng/mL after vitamin D supplementation with a mean weekly dose of 88,865 IU. There were no differences between the placebo and vitamin D groups regarding fasting plasma glucose, 2-h glucose, or insulin secretion and sensitivity or in the percent developing diabetes or returning to normal glucose tolerance. No subjects experienced increased serum or urinary calcium levels. At 12 months, A1C levels were significantly slightly less (0.2%) in the vitamin D group.
Conclusions
In individuals with prediabetes and hypovitaminosis D, doses of vitamin D supplementation designed to raise serum 25-OHD levels into the upper-normal range for 1 year had no effect on insulin secretion, insulin sensitivity, or the development of diabetes compared with placebo administration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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