Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials
Hu T, Mills KT, Yao L, Demanelis K, Eloustaz M, Yancy WS, Kelly TN, He J, Bazzano LA
American journal of epidemiology · 249 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tulane University
- Gobierno
- National Institutes of Health
- Universidad u hospital
- School of Medicine, Duke University
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (K08 HL091108)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2012-10-01 · Am J Epidemiol · vol. 176 · número suppl_7 · págs. S44–S54
- Editorial
- Oxford University Press
- Citado
- 418 citas · más que el 93% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Diet and metabolism studies · Dietary Effects on Health · Nutritional Studies and Diet
- Palabras clave
- low-carbohydrate diet, low-fat diet, metabolic risk factors, weight loss, obesity, cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, waist circumference, dietary fat restriction
- MeSH
- humans, body weight, cholesterol, insulin, blood glucose, triglycerides, diet, fat-restricted, risk factors, age factors, sex factors, blood pressure, adult, middle aged, female, male, diet, carbohydrate-restricted, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic, waist circumference, young adult, metabolic syndrome
9 autores
- Tian Hu🇺🇸Tulane University
- Katherine T. Mills🇺🇸Tulane University
- Lu Yao🇺🇸Tulane University
- Kathryn Demanelis🇺🇸Tulane University
- Mohamed H. Eloustaz🇺🇸Tulane University
- William S. Yancy🇺🇸Tulane University; Duke University
- Tanika N. Kelly🇺🇸Tulane University
- Jiang He🇺🇸Tulane University
- Lydia Bazzano🇺🇸 · autor de correspondenciaTulane University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of low-carbohydrate diets (≤45% of energy from carbohydrates) versus low-fat diets (≤30% of energy from fat) on metabolic risk factors were compared in a meta-analysis of randomized controlled trials. Twenty-three trials from multiple countries with a total of 2,788 participants met the predetermined eligibility criteria (from January 1, 1966 to June 20, 2011) and were included in the analyses. Data abstraction was conducted in duplicate by independent investigators. Both low-carbohydrate and low-fat diets lowered weight and improved metabolic risk factors. Compared with participants on low-fat diets, persons on low-carbohydrate diets experienced a slightly but statistically significantly lower reduction in total cholesterol (2.7 mg/dL; 95% confidence interval: 0.8, 4.6), and low density lipoprotein cholesterol (3.7 mg/dL; 95% confidence interval: 1.0, 6.4), but a greater increase in high density lipoprotein cholesterol (3.3 mg/dL; 95% confidence interval: 1.9, 4.7) and a greater decrease in triglycerides (-14.0 mg/dL; 95% confidence interval: -19.4, -8.7). Reductions in body weight, waist circumference and other metabolic risk factors were not significantly different between the 2 diets. These findings suggest that low-carbohydrate diets are at least as effective as low-fat diets at reducing weight and improving metabolic risk factors. Low-carbohydrate diets could be recommended to obese persons with abnormal metabolic risk factors for the purpose of weight loss. Studies demonstrating long-term effects of low-carbohydrate diets on cardiovascular events were warranted.
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